79114-07-1

Upstream product

• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 122-59-8 2-phenoxyacetic acid 
• 701-99-5 Phenoxyacetyl chloride 
• 1613-90-7 4-methoxy-N-[(E)-phenylmethylidene]aniline 
• 100-52-7 benzaldehyde 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 1227-44-7 N,N'-bis(4-methoxyphenyl)urea 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 32546-83-1 (Z)-1-phenyl-2-phenoxyethene 
• 66694-17-5 (E)-2-phenyl-1-phenoxyethene 

Relevant academic research and scientific papers

Biological evaluation in vitro and in silico of azetidin-2-one derivatives as potential anticancer agents

Potential anticancer activity of 16 azetidin-2-one derivatives was evaluated showing that compound 6 [N-(p-methoxy-phenyl)-2-(p-methyl-phenyl)-3-phenoxy-azetidin-2-one] presented cytotoxic activity in SiHa cells and B16F10 cells. The caspase-3 assay in B1

Synthesis of β-lactams via Staudinger reaction using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline as a carboxylic acid activator

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) has been used as an efficient and convenient reagent for the one-pot synthesis of β-lactams by [2+2] ketene–imine cycloaddition (Staudinger reaction). Cleanliness, simplicity of method, and good to exc

Preparation of 2-azetidinones by cyclocondensation of carboxylic acids and imines via diphosphorustetraiodide

One-pot mild synthesis of 2-azetidinones was carried out by the reaction of imines and carboxylic acids in dry dichloromethane at room temperature using diphosphorus tetraiodide. It was also applied for synthesis of 3-spiro-2-azetidinones. The synthesized

Pyrolysis of azetidinone derivatives: A versatile route towards electron-rich alkenes, C-1 allylation and/or homologation of aldehydes

Pyrolysis of β-lactams and β-thiolactams led essentially to stereoselective synthesis of the high energy electron-rich Z-alkenes. Extension of this methodology to the pyrolysis of 3-allyloxy derivatives gave a simple direct route to the synthetically important 4-pentenal. These pyrolytic transformations convert aldehydes to aryloxyalkenes (a protected homologation) and 4-pentenal (a C-1 allylation and homologation). The starting 3-aryloxy and 3-allyloxy-β-lactams were synthesized by the standard Staudinger ketene-imine [2 + 2] cycloaddition. The corresponding β-thiolactams have readily been obtained in good yields by thiation of β-lactams with Lawesson's reagent. This journal is the Partner Organisations 2014.

Solvent-free, one-pot synthesis of β-lactams by the Sc(OTf) 3-catalyzed reaction of silyl ketene thiocetals with imines

A solvent-free, catalytic, one-pot synthesis of β-lactams is described. The reaction involves the reaction between silyl ketene thioacetals derived from 2-pyridyl thioesters and imines at room temperature in the presence of catalytic amounts of Sc(OTf)su

Reductive ring opening of 2-azetidinones promoted by sodium borohydride

Variously substituted 2-azetidinones 3 and 4 were reacted with sodium borohydride in aqueous isopropanol giving 3-aminopropan-1,2-dioles 5 and 7. Reaction extent was dependent upon the substitution pattern in the 3- and 4-positions of the 2-azetidinone ri

A new polymer-supported reagent for the synthesis of β-lactams in solution

A modified Mukaiyama reagent was prepared on a PS-DVB resin. This reagent was used for the preparation of β-lactams, using the Staudinger reaction. The products were obtained by generating the ketene from a carboxylic acid under sonication with the resin followed by reaction with the imine. Excess of the imine was removed by reduction followed by acid scavenging.

Triphosgene: A versatile reagent for the synthesis of azetidin-2-ones

An efficient use of triphosgene, as an acid activator, for the synthesis of substituted azetidin-2-ones via ketene-imine cycloaddition reaction using various acids and imines have been described.

Synthesis of azetidin-2-one via in situ generated acid chlorides using hexachloroacetone-triethylphosphite

A one step synthesis of azitidine-2-ones 3a-i has been described by the reaction of imines 2 with acids 1 in the presence of hexachloroacetone, triethylphosphite and triethylamine.

Triphosgene, an efficient acid activator for the Staudinger reaction

An efficient one-step synthesis of β-lactams by the reaction of imines with acids in the presence of triphosgene and triethylamine has been described.