1227-44-7Relevant academic research and scientific papers
Super fast cobalt carbonyl-mediated synthesis of ureas
Enquist, Per-Anders,Nilsson, Peter,Edin, Johan,Larhed, Mats
, p. 3335 - 3339 (2005)
Fast cobalt carbonyl-mediated generation of ureas from primary amines was performed using high-density microwave irradiation. This enhanced method permitted the preparation of symmetrical ureas in good yields and unsymmetrical ureas in moderate yields. Th
Cationic Rhodium(III)-Catalyzed Direct C-2 Carboxamidation of Indoles with Isocyanates via C-H Bond Functionalization
Xu, Jun,Sharma, Nandini,Sharma, Upendra K.,Li, Zhenghua,Song, Gonghua,Van Der Eycken, Erik V.
, p. 2615 - 2621 (2015)
A pentamethylcyclopentadienylrhodium(III)-catalyzed regioselective synthesis of indole-2-carboxamides is described employing N-pyrimidylindoles and isocyanates as coupling partners via C-H functionalization. A wide variety of indole-2-carboxamides can be
Exploratory studies towards various anion recognition chemistry by two different sized cleft shaped organic ligands
Roychowdhury, Additi,Ghosh, Pritam,Saha, Sourav Kr.,Mitra, Partha,Banerjee, Priyabrata
, p. 492 - 499 (2014)
Indole and urea based two organic receptors have been synthesized by an easy synthetic process. These two receptors have strong sensitivity and selectivity for several bio-relevant anions. Receptor 1 and 2 were synthesized from indole-2-carboxylic acid an
Electrochemically controlled hydrogen bonding. O-quinones as simple redox-dependent receptors for arylureas
Ge,Miller,Ouimet,Smith
, p. 8831 - 8838 (2000)
9,10-Phenanthrenequinone and acenaphthenequinone are shown to act as simple redox-dependent receptors toward aromatic ureas in CH2Cl2 and DMF. Reduction of the o-quinones to their radical anions greatly increases the strength of hydr
Anion-Coordination-Assisted Assembly of Supramolecular Charge-Transfer Complexes Based on Tris(urea) Ligands
Feng, Hong-Jian,He, Jia-Wei,Hou, Le-Kai,Würthner, Frank,Wu, Biao,Yang, Xiao-Juan,Zhang, Dan,Zhang, Qiang
, p. 1414 - 1421 (2020)
Charge-transfer (CT) complexes, formed by noncovalent bonding between electron-rich (donor, D) and electron-deficient (acceptor, A) molecules (or moieties) have attracted considerable attention due to their fascinating structures and potential application
[3+3] Annulation via Ring Opening/Cyclization of Donor–Acceptor Cyclopropanes with (Un)symmetrical Ureas: A Quick Access to Highly Functionalized Tetrahydropyrimidinones
Taily, Irshad Maajid,Saha, Debarshi,Banerjee, Prabal
, p. 7804 - 7813 (2019)
A mild and straight-forward access to pharmacologically privileged tetrahydropyrimidinones exploiting readily available Donor–Acceptor cyclopropanes (DACs) is reported. This methodology involves the Lewis acid catalyzed synthesis of uriedo-malonates from (un)symmetrical ureas and DACs followed by I2-base mediated cyclization to their corresponding tetrahydropyrimidinones. The cyclization protocol involves nucleophilic attack of the nitrogen of urea on the newly generated electrophilic acceptor end of DAC. The post functionalization offered potential biologically active molecules.
A high yielding, one-pot synthesis of substituted ureas from the corresponding amines using Mitsunobu's reagent
Chaturvedi, Devdutt,Mishra, Nisha,Mishra, Virendra
, p. 267 - 270 (2008)
A Mitsunobu-based protocol has been developed for the synthesis of symmetrically and unsymmetrically substituted ureas from a variety of primary and secondary amines using gaseous carbon dioxide, in good to excellent yields. This protocol is mild and efficient compared to other reported methods.
Oxovanadium(v)-catalyzed amination of carbon dioxide under ambient pressure for the synthesis of ureas
Moriuchi, Toshiyuki,Sakuramoto, Takashi,Matsutani, Takanari,Kawai, Ryota,Donaka, Yosuke,Tobisu, Mamoru,Hirao, Toshikazu
, p. 27121 - 27125 (2021/08/24)
Carbon dioxide is regarded as a reliable C1 building block in organic synthesis because of the nontoxic, abundant, and economical characteristics of carbon dioxide. In this manuscript, a commercially available oxovanadium(v) compound was demonstrated to serve as an efficient catalyst for the catalytic amination of carbon dioxide under ambient pressure in the synthesis of ureas. The catalytic transformation of chiral amines into the corresponding chiral ureas without loss of chirality was also performed. Furthermore, a gram-scale catalytic urea synthesis under ambient pressure was successfully achieved to validate the scalability of this catalytic activation of carbon dioxide. This journal is
Di-tert-butyl peroxide (DTBP)-mediated synthesis of symmetrical N,N′-disubstituted urea/thiourea motifs from isothiocyanates in water
Chen, Ling,Dong, Yibo,Wu, Yangjie,Yang, Jinchen,Zhang, Jinli
supporting information, (2021/12/01)
ABATRACT: A direct approach to N,N′-disubstituted urea/thiourea from the self-condensation reactions of isothiocyanates in water has been developed. This access tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to N,N′-disubstituted urea/thiourea in moderate to excellent yields from safe and easily available starting materials. A plausible mechanism of the desulfurization self-condensation reaction for urea was also proposed and the role of di-tert-butyl peroxide (DTBP) and copper catalyst in the present strategy was demonstrated with the help of ESI mass spectrometry of intermediate studies.
Amide-assisted rearrangement of hydroxyarylformimidoyl chloride to diarylurea
Jin, Yi,Liu, Xiaoyu,Song, Xizhong,Yu, Wei
supporting information, (2021/11/11)
A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented.
