79144-57-3Relevant academic research and scientific papers
Efficient Generation and Synthetic Applications of Alkyl-Substituted Siloxycarbenes: Suppression of Norrish-Type Fragmentations of Alkanoylsilanes by Triplet Energy Transfer
Abe, Manabu,Hagiwara, Chihiro,Ishida, Kento,Kusama, Hiroyuki,Yamazaki, Hokuto
supporting information, p. 1249 - 1253 (2020/02/04)
Acylsilanes have been known to undergo isomerization to siloxycarbenes under photoirradiation and the thus generated carbenes can be utilized for various synthetic reactions. But this carbene formation is not necessarily efficient with some alkanoylsilanes because Norrish-type fragmentations compete, which limit the synthetic utility of alkanoylsilanes as carbene precursors. In this study, generation of siloxycarbenes from alkanoylsilanes by visible-light-induced energy transfer was examined by using an Ir complex, [Ir{dF(CF3)ppy}2(dtbpy)]PF6, and was successfully applied to the C?C coupling reactions with boronic esters or aldehydes. This methodology efficiently suppressed undesired Norrish-type reactions and broadened synthetic utility of alkanoylsilanes.
Biogentic amine uptake inhibitors
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, (2008/06/13)
Compounds of the formula: STR1 or a pharmaceutically acceptable salt thereof, wherein m is 0, 1 or 2 and n is 0 or 1; R1 is hydrogen or lower alkyl; R2 is C1 -C6 -alkyl substituted with a heterocyclic group or C7 -C16 -arylalkyl, wherein the aryl group is unsubstituted or substituted with from one to three non-hydrogen members independently selected from the group consisting of halogen, C1 -C6 -alkyl, halo-C1 -C6 -alkyl, C1 -C6 -alkoxy, hydroxy, amino and C1 -C6 -alkylamino; R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen, C1 -C6 -alkoxy, C1 -C6 -alkyl, halogen, and halo-C1 -C6 -alkyl, or any two of R3, R4, R5 and R6 taken together form a methylenedioxy group; and R7 is hydrogen or C1 -C6 -alkyl. These compounds are useful as inhibitors of the neuronal uptake of biogenic amines and for the treatment of affective disorders, such as, for example, depression.
On the McLafferty Rearrangement of Ionized Phenyl Pyridyl Alkanones
Richter, Bernd,Schwarz, Helmut
, p. 865 - 877 (2007/10/02)
A detailed investigation concerning the genesis of McLafferty rearrangement products from molecular ions of phenyl pyridyl alkanones reveals the following features: 1) The various products are not formed by competitive dissociations of the molecular ion.Most of the relevant fragment ions are generated from the primary McLafferty product of a hydrogen transfer to the ionized carbonyl group (M+*-->m/z 163, ion k).The ion k plays a decisive role for the generation of the abundant product ions at m/z 93 (ion g) and m/z 106 (ion s) both of which are formed by further dissociation of k.Details of the mechanisms for the decomposition of k are obtained by investigating -labelled isotopomers, the analysis of low and high resolution data, the application of MIKE and CA spectra.The problem of keto/enol tautomerism between some ions, relevant in this context, is discussed and it is shown that these isomerization processes are not involved.A detailed description is given for the syntheses of various -labelled phenyl pyridyl alkanones. - Keywords: Mass Spectrometry, Hydrogen Rearrangement, Keto Enol Tautomerism, Metastable Ions, Collisional Activation
