79146-99-9

Upstream product

• 96-50-4 2-thiazolylamine 
• 1871-38-1 phenyl 4-chlorobenzoate 
• 122-01-0 4-chloro-benzoyl chloride 
• 59775-49-4 2-<(p-chlorobenzylidene)amino>thiazole 
• 637-87-6 1-Chloro-4-iodobenzene 
• 124-38-9 carbon dioxide 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 13159-90-5 (4-chloro-benzyl)-thiazol-2-yl-amine 

Relevant academic research and scientific papers

Aminothiazoles and aminothiadiazoles as nucleophiles in aminocarbonylation of iodobenzene derivatives

Various 2-, 3- and 4-substituted iodobenzenes were aminocarbonylated using aminothiazole and aminothiadiazole derivatives in palladium-catalysed reaction. The reaction is chemospecific toward the corresponding carboxamides. Consequently, the application o

Facile synthesis of N-acyl 2-aminobenzothiazoles by NHC-catalyzed direct oxidative amidation of aldehydes

A mild, general, and high yielding synthesis of N-acyl 2-aminobenzothiazoles has been demonstrated by N-heterocyclic carbene (NHC)-organocatalyzed direct amidation of aldehydes with 2-aminobenzothiazoles proceeding via acyl azolium intermediates. The carbene generated from the triazolium salt under oxidative conditions was the key for the success of this reaction. The method was subsequently applied to the synthesis of various biologically important N-acyl 2-aminobenzothiazoles.

Access to Amide from Aldimine via Aerobic Oxidative Carbene Catalysis and LiCl as Cooperative Lewis Acid

Herein, an efficient route to amides from aldimines via aza-Breslow intermediates through aerobic oxidative carbene catalysis with LiCl as a cooperative Lewis acid is described. Many of the obtained N-heteroarylamides feature biological activity. Ambient

Ring-opened analogs of indomethacin affecting human neutrophil functions

A series of ring-opened analogs of indomethacin was synthesized and tested in vitro (at concentrations ranging from 10-9 to 10-5 mol/1) on human neutrophil functions. Two compounds lacking the carboxylic group were subjected to the s