791613-70-2

Upstream product

• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 787633-79-8 (R,S)-1-(4-chloro-2-nitrophenyl)ethanol 
• 39637-74-6 (1S)-(-)-camphanic chloride 

Downstream Products

• 907198-92-9 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-1-[3-(4-methyl-piperazin-1-yl)-propyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 907198-49-6 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-1-(2-morpholin-4-yl-ethyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 907198-70-3 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 898222-45-2 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 898222-43-0 2-[(R)-1-(4-Chloro-2-nitro-phenyl)-ethyl]-isoindole-1,3-dione 
• 898222-44-1 (R)-1-(4-Chloro-2-nitro-phenyl)-ethylamine 
• 898222-42-9 (S)-1-(4-Chloro-2-nitro-phenyl)-ethanol 

Relevant academic research and scientific papers

Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists

The 1,4-benzodiazepine-2,5-dione is a suitable template to disrupt the interaction between p53 and Hdm2. The development of an enantioselective synthesis disclosed the stereochemistry of the active enantiomer. An in vitro p53 peptide displacement assay identified active compounds. These activities were confirmed in several cell-based assays including induction of the p53 regulated gene (PIG-3) and caspase activity.

Combinational therapy involving a small molecule inhibitor of the MDM2: P53 interaction

The present invention is directed to a combinational therapy for treating cancer or other cell proliferative diseases. Such a therapy combines the use of radiation therapy or chemotherapy with the use of a small molecule inhibitor of the MDM2: p53 interaction.