907198-92-9

Basic information

• Product Name: 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-1-[3-(4-methyl-piperazin-1-yl)-propyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
• CAS NO: 907198-92-9
• Molecular Weight: 736.437
• Mol File: 907198-92-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-1-[3-(4-methyl-piperazin-1-yl)-propyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-1-[3-(4-methyl-piperazin-1-yl)-propyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione(907198-92-9)
• EPA Substance Registry System: 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-1-[3-(4-methyl-piperazin-1-yl)-propyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione(907198-92-9)

Safety Data

• Hazardous Substances Data: 907198-92-9(Hazardous Substances Data)

Upstream product

• 898222-45-2 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 898222-43-0 2-[(R)-1-(4-Chloro-2-nitro-phenyl)-ethyl]-isoindole-1,3-dione 
• 898222-44-1 (R)-1-(4-Chloro-2-nitro-phenyl)-ethylamine 
• 787633-79-8 (R,S)-1-(4-chloro-2-nitrophenyl)ethanol 
• 791613-70-2 [(S)-1-(4-chloro-2-nitrophenyl)ethyl] (1S)-camphanoate 
• 898222-42-9 (S)-1-(4-Chloro-2-nitro-phenyl)-ethanol 

Relevant articles and documents

Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists

The 1,4-benzodiazepine-2,5-dione is a suitable template to disrupt the interaction between p53 and Hdm2. The development of an enantioselective synthesis disclosed the stereochemistry of the active enantiomer. An in vitro p53 peptide displacement assay identified active compounds. These activities were confirmed in several cell-based assays including induction of the p53 regulated gene (PIG-3) and caspase activity.