898222-44-1

Basic information

• Product Name: Benzenemethanamine, 4-chloro-a-methyl-2-nitro-, (aR)-
• Synonyms: Benzenemethanamine, 4-chloro-a-methyl-2-nitro-, (aR)-;Benzenemethanamine, 4-chloro-α-methyl-2-nitro-, (αR)-;Benzenemethanamine, 4-chloro-.alpha.-methyl-2-nitro-, (.alpha.R)-;4-chloro-a-Methyl-2-nitro-;(1R)-1-(4-chloro-2-nitrophenyl)ethanamine
• CAS NO: 898222-44-1
• Molecular Formula: C₈H₉ClN₂O₂
• Molecular Weight: 200.624
• Product Categories: API intermediates
• Mol File: 898222-44-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenemethanamine, 4-chloro-a-methyl-2-nitro-, (aR)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 4-chloro-a-methyl-2-nitro-, (aR)-(898222-44-1)
• EPA Substance Registry System: Benzenemethanamine, 4-chloro-a-methyl-2-nitro-, (aR)-(898222-44-1)

Safety Data

• Hazardous Substances Data: 898222-44-1(Hazardous Substances Data)

Usage

General Description

Benzenemethanamine, 4-chloro-a-methyl-2-nitro-, (aR)- is a chemical compound with the molecular formula C9H10ClN3O2. It is a chiral compound, meaning it has a non-superimposable mirror image, and the (aR)- designation indicates the stereochemistry of the molecule. Benzenemethanamine, 4-chloro-a-methyl-2-nitro-, (aR)- is often used in the synthesis of pharmaceuticals and agrochemicals, and it may also have potential applications in the field of medicinal chemistry. The presence of a nitro group and a chlorine atom in the molecule gives it unique chemical properties and potential reactivity, which may be of interest to researchers and chemists studying organic synthesis and chemical reactions.

Upstream product

• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 791613-70-2 [(S)-1-(4-chloro-2-nitrophenyl)ethyl] (1S)-camphanoate 
• 898222-42-9 (S)-1-(4-Chloro-2-nitro-phenyl)-ethanol 
• 787633-79-8 (R,S)-1-(4-chloro-2-nitrophenyl)ethanol 
• 898222-43-0 2-[(R)-1-(4-Chloro-2-nitro-phenyl)-ethyl]-isoindole-1,3-dione 

Downstream Products

• 898222-45-2 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 907198-70-3 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-1-[2-(2-methoxy-ethoxy)-ethyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 907198-49-6 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-1-(2-morpholin-4-yl-ethyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 907198-92-9 4-[1-(4-chloro-2-nitro-phenyl)-ethyl]-3-(4-chloro-phenyl)-7-iodo-1-[3-(4-methyl-piperazin-1-yl)-propyl]-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 

Relevant articles and documents

Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists

The 1,4-benzodiazepine-2,5-dione is a suitable template to disrupt the interaction between p53 and Hdm2. The development of an enantioselective synthesis disclosed the stereochemistry of the active enantiomer. An in vitro p53 peptide displacement assay identified active compounds. These activities were confirmed in several cell-based assays including induction of the p53 regulated gene (PIG-3) and caspase activity.