79360-11-5Relevant academic research and scientific papers
Synthesis of a dexamethasone-21-maleimido-linked derivative as a potential molecule for specific gene delivery
Bernasconi, A.,Rebuffat, A.,Bigler, P.,Frey,Frey
, p. 6511 - 6513 (2001)
The synthesis of the dexamethasone-21-maleimido-linked derivative 5 is described for the first time. The two principal steps of this synthesis are (1) the formation of a stable urethane 3 and (2) the introduction of a reactive maleimido group via a linker
TARGETED STEROID CONJUGATES
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Paragraph 00309; 00311; 00320; 00321, (2021/07/17)
A compound of the formula (I): G1-L-G2, or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein G1 is a folate radical, an antifolate radical, or a folate analog radical; L is a linker; and G2 is a radical of a steroid; compositions comprising such compounds; and the use of such compounds and compositions to treat, for example, inflammation associated with a disease or disorder.
CONJUGATES OF CARTILAGE-HOMING PEPTIDES
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Paragraph 0363; 0365, (2019/11/12)
Compositions such as pharmaceutical compositions and uses for peptide-drug conjugates are disclosed. Such compositions can deliver a drug, a peptide, or a conjugate thereof to a target region, tissue, structure or cell in cartilage.
GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING GLUCOCORTICOID RECEPTOR ACTIVITY
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Paragraph 00966, (2013/06/05)
Provided herein are glucagon superfamily peptides conjugated with GR ligands that are capable of acting at a glucocorticoid receptor. Also provided herein are pharmaceutical compositions and kits of the conjugates of the invention. Further provided herein
Conjugates of DNA interacting groups with steroid hormones for use as nucleic acid transfection agents
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Page column 18, (2010/02/07)
The present invention relates to novel compounds comprising a steroid hormone linked to a DNA-interacting molecule that target nucleic acids to the cell nucleus. Further, the invention relates to a method for introducing nucleic acids into the nucleus of
Cell-Specific Ligands for Selective Drug Delivery to Tissues and Organs
Ponpipom, Mitree M.,Bugianesi, Robert L.,Robbins, James C.,Doebber, T. W.,Shen, T. Y.
, p. 1388 - 1395 (2007/10/02)
Various numbers of D-mannose residues have been attached via spacer arms to lysine, dilysine, and oligolysine backbones.These D-mannosyl peptide analogues were found to be potent competitive inhibitors of the uptake of 125I-labelled D-mannose-bovine serum
