79461-71-5

Upstream product

• 24005-23-0 2-phenyl-1,2,3,4-tetrahydroquinoline 
• 74-88-4 methyl iodide 
• 887-94-5 1-methyl-2-phenyl-1,2-dihydroquinoline 
• 79461-67-9 1-Methyl-2-(4-oxo-4-phenyl-butyl)-pyridinium; iodide 
• 74-89-5 methylamine 
• 64-17-5 ethanol 
• 7153-77-7 1-phenyl-4-[2]pyridyl-butan-1-one 
• 3947-76-0 N-methylquinolinium iodide 
• 67-68-5 dimethyl sulfoxide 
• 446-52-6 2-Fluorobenzaldehyde 
• 1486473-54-4 N-benzyl-N-methyl-2-vinylaniline 
• 103-67-3 benzyl-methyl-amine 
• 1020957-75-8 2-((benzyl)methylamino)benzaldehyde 
• 22965-99-7 (E)-3-(2-methoxylphenyl)-1-phenylprop-2-en-1-one 

Relevant academic research and scientific papers

Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite

A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution.

α-Alkylation of tertiary amines by C(sp3)–C(sp3) cross-coupling under redox neutral photocatalysis

Direct α-alkylation of N-phenyl-tetrahydroisoquinoline with alkyl selenides of desired alkyl chain length and functionality is reported by photoredox catalysis. Construction of hexahydro pyrrolo- and pyrido-isoquinoline scaffolds along with indolines and tetrahydroquinolines is also described by intramolecular C(sp3)–C(sp3) cross-couplings.

A general method for N-methylation of amines and nitro compounds with dimethylsulfoxide

DMSO methylates a broad range of amines in the presence of formic acid, providing a novel, green and practical method for amine methylation. The protocol also allows the one-pot transformation of aromatic nitro compounds into dimethylated amines in the presence of a simple iron catalyst. Not just a solvent: DMSO methylates a broad range of amines in the presence of formic acid, providing a novel, green and practical method for amine methylation. The protocol also allows the one-pot transformation of aromatic nitro compounds into dimethylated amines in the presence of a simple iron catalyst. Copyright

Efficient cyclization of tertiary amines and alkenes promoted by KOt-Bu-DMF

Nitrogen heterocycles could be prepared in good yields via intramolecular cyclization of tertiary amines and alkenes promoted by KOt-Bu-DMF. This journal is The Royal Society of Chemistry 2013.

Rapid synthesis of the tetrahydroquinoline alkaloids: angustureine, cuspareine and galipinine

A one-pot method for the preparation of 1,2-substituted dihydroquinolines is described. This method features the C-2 addition of a range of organolithium reagents to quinoline followed by the in-situ addition of an electrophile. Standard palladium-catalys

Hypoglycemic thiazolidinediones

Hypoglycemic 5-[1-(5,6,7,8-tetrahydro-2-napthyl-; 1,2,3,4-tetrahydro-6-quinolyl-; 2-indanyl-; and 2-indolyl)alkyl]thiazolidine-2,4-dione derivatives, pharmaceutically acceptable salts thereof, and a method for their use in the treatment of hyperglycemic mammals.

ISOMERIZATION RECYCLIZATION OF PYRIDYLETHYLATED KETONES. NEW METHOD FOR THE SYNTHESIS OF QUINOLINE DERIVATIVES

Quinolines and 1,2,3,4-tetrahydroquinolines were obtained by heating quarternary salts of pyridylethylated ketones with sulfites of primary amines in an ampul. 1-Tetralone or substituted 2-tetralones are formed as side products.Substituted 1,4-dihydoquino