795-36-8

Usage

Uses

Used in Pharmaceutical Industry:
1,1,1-triphenylpropan-2-one is used as a building block for the synthesis of various pharmaceuticals and synthetic products, contributing to the development of new drugs and medicines.
Used in Polymer Industry:
1,1,1-triphenylpropan-2-one is used as a photoinitiator in photopolymerization reactions, facilitating the process of polymer formation under the influence of light.
Used in Food Industry:
1,1,1-triphenylpropan-2-one is used as a flavoring agent, enhancing the taste and aroma of various food products.
Used in Antimicrobial Applications:
1,1,1-triphenylpropan-2-one has been studied for its potential antioxidant properties and its ability to inhibit the growth of certain bacteria and fungi, making it a candidate for use in antimicrobial applications.
It is important to handle 1,1,1-triphenylpropan-2-one with care, as it is considered potentially harmful if ingested or inhaled and may cause skin and eye irritation.

InChI:InChI=1/C21H18O/c1-17(22)21(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16H,1H3

Upstream product

• 56-23-5 tetrachloromethane 
• 917-64-6 methyl magnesium iodide 
• 60-29-7 diethyl ether 
• 6068-70-8 triphenylacetyl chloride 
• 4237-46-1 α-phenylbenzoin 
• 3784-22-3 1,1,2-triphenylpropane-1,2-diol 
• 67-66-3 chloroform 
• 90141-58-5 acetic acid-(N'-trityl-hydrazide) 
• 79-15-2 N-bromoacetamide 
• 595-91-5 triphenylacetic acid 
• 75-24-1 trimethylaluminum 
• 97990-95-9 1,1,1-Triphenyl-2-propanol 
• 926-67-0 O-Ethyl thioacetate 
• 981-18-0 triphenyl(phenylazo)methane 

Downstream Products

• 115917-76-5 1,4,4,4-tetraphenyl-butane-1,3-dione 
• 112686-73-4 1,1,1-triphenyl-pentane-2,4-dione 
• 72152-17-1 1,1,1,4-tetraphenyl-but-3-en-2-one 
• 72152-16-0 1,1,1-Triphenyl-3-penten-2-on 
• 54759-37-4 4-Hydroxy-4-methyl-1,1,1-triphenyl-2-pentanon 
• 139164-44-6 (R)-1-tritylethanol 
• 104335-99-1 3-Methyl-1,1,1-triphenyl-3-hexen-2-on 
• 519-73-3 triphenylmethane 
• 64-19-7 acetic acid 
• 72152-27-3 1,1,1-Triphenyl-decan-2-one 
• 102478-80-8 1,1,1-triphenyl-propan-2-one oxime 
• 104336-00-7 3,3-Dimethyl-1,1,1-triphenyl-4-hexen-2-on 
• 143430-71-1 1-t-butyl 5-methyl (1'R,2R,5R)-2-(t-butyl)-3-methyl-5-<1'-methyl-3'-oxo-4',4',4'-triphenylbutyl>-1,5-imidazolidinedicarboxylate 
• 143430-67-5 t-butyl (1'S,2R,5R)-2-(t-butyl)-3-methyl-5-<1'-methyl-3'-oxo-4',4',4'-triphenylbutyl>-4-oxo-1-imidazolidinecarboxylate 

Relevant academic research and scientific papers

Trityl-containing alcohols—an efficient chirality transmission process from inductor to the stereodynamic propeller and their solid-state structural diversity

The cascade process of a dynamic chirality transmission from the permanent chirality center to the stereodynamic triphenylmethyl group has been studied for series of optically active trityl derivatives. The structural analysis, carried out with the use of complementary methods, enabled us to determine the mechanism of chirality transfer. The process of chirality transmission involves a set of weak but complementary electrostatic interactions. The induction of helicity in a trityl propeller is revealed by rising non-zero cotton effects in the area of trityl UV-absorption. The presence of an additional stereogenic center in close proximity to the trityl-containing stereogenic center significantly affects the sign and, to a lesser extent, magnitude of the respective cotton effects. Despite the bulkiness of the trityl, in the crystalline phase, the molecules under study strictly fill the space. In the crystal, molecules form aggregates stabilized by OH???O hydrogen bonds. However, the presence of two trityl groups precludes formation of OH???O hydrogen bonding. Additionally, the trityl group seems to be responsible for the formation of the solid solutions by e.g., racemates of trans- and cis-2-tritylcyclohexanol. Therefore, the trityl group acts as a supramolecular protective group, which in turn can be used in the crystal engineering.

A one-pot cross-pinacol coupling/rearrangement procedure

A new catalytic retro-pinacol/cross-pinacol reaction, followed by subsequent rearrangement or deoxygenation of the intermediately formed vicinal diols, is described. This operationally simple one-pot protocol allows isolation of geminal α,α-diphenyl ketones or 1,1-diphenyl alkenes with high yields and selectivities. Copyright

Cyanocuprates convert carboxylic acids directly into ketones

Carboxylic acids were converted directly in 56-99% yields into methyl, n-butyl, and isopropyl ketones using excess cyanocuprates R2CuLi 3 LiCN. A substrate with a stereocenter α to the carboxylic acid was converted into ketones with very little loss of enantiomeric purity. A variety of functional groups were tolerated including aryl bromides. This direct transformation of a carboxylic acid into ketone with minimal tertiary alcohol formation is proposed to involve a relatively stable copper ketal tetrahedral intermediate.

Imines as ion channel modulators

The present invention provides a class of chemical compounds useful in the treatment of sickle cell disease, diseases characterized by unwanted or abnormal cell proliferation and for the treatment of ocular disorders such as glaucoma. The active compounds

Diastereoselective Michael Additions of Chiral Imidazolidines to Trityl Enones

The enolates A and C of t-butyl (R)-2-t-butyl-3-methyl-4-oxo-1-imidazolidinecarboxylate (1, Boc-BMI) and of 1-t-butyl 5-methyl (2R,5S)-2-t-butyl3-methyl-1,5-imidazolidinedicarboxylate (3) and t-butyl (R)-2-t-butyl-5-lithio-3-methyl-1-imidazolidinecarboxyl

Tritylketones and Tritylenones. Contribution to the Sterically Enforced Michael Addition and to the Diastereoselective Aldol Addition

Tritylketones are prepared from trityllithium and aldehydes, with subsequent CrO3 oxidation (Scheme 1, 2a-f).Tritylenones are obtained from the saturated ketones and aldehydes or ketones, preferably by (CH3)3Al-mediated aldol addition with subsequent dehy