79574-77-9

Basic information

• Product Name: Methanone, [2-(methylamino)-3-pyridinyl]phenyl-
• CAS NO: 79574-77-9
• Molecular Formula: C13H12N2O
• Molecular Weight: 212.251
• Mol File: 79574-77-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Methanone, [2-(methylamino)-3-pyridinyl]phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [2-(methylamino)-3-pyridinyl]phenyl-(79574-77-9)
• EPA Substance Registry System: Methanone, [2-(methylamino)-3-pyridinyl]phenyl-(79574-77-9)

Safety Data

• Hazardous Substances Data: 79574-77-9(Hazardous Substances Data)

Upstream product

• 79574-62-2 2-fluoro-3-(phenyl-1-hydroxymethyl)pyridine 
• 100-52-7 benzaldehyde 
• 372-48-5 2-fluoropyridine 
• 2942-59-8 2-chloronicotinic acid 
• 80099-81-6 3-benzoyl-2-chloro-pyridine 
• 74-89-5 methylamine 
• 79574-71-3 (2-fluoropyridin-3-yl)phenylmethanone 

Downstream Products

• 178548-71-5 N-(3-benzoyl-2-pyridyl)-N-methylpropionamide 
• 178548-60-2 N-(3-Benzoyl-2-pyridyl)-N-methylacetamide 

Relevant articles and documents

Synthetic studies on selective type 4 phosphodiesterase (PDE 4) inhibitors. 1. Structure-activity relationships and pharmacological evaluation of 1,8-naphthyridin-2(1H)-one derivatives.

In order to develop novel and orally active phosphodiesterase (PDE) 4 inhibitors, random screening was performed using our chemical library to find YM-10335 possessing the 1,8-naphthyridin-2(1H)-one skeleton which is a completely different structure from rolipram. In this report, the syntheses and structure-activity relationships of the YM-10335 derivatives were described. Some compounds showed selective inhibitory activities for PDE 4 derived from human peripheral blood cells and no effect on the other PDE types (1, 2, 3, 5). The inhibition of the tumor necrosis factor-alpha (TNF-alpha) release in vitro and the carrageenan-induced pleurisy in rats were also described.