79603-03-5

Usage

Uses

Used in Organic Synthesis:
BENZONITRILE, 4-BROMO-2-NITROis used as a chemical intermediate for the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable component in the creation of new molecules and materials.
Used in Research:
BENZONITRILE, 4-BROMO-2-NITROis used as a research compound to study its properties and potential applications in various fields. Its presence of a polar C≡N triple bond and other characteristics make it an interesting subject for scientific investigation.
Used in Industrial Applications:
BENZONITRILE, 4-BROMO-2-NITROis used in the industrial setting primarily for the creation of chemical intermediates, which are essential for the production of various chemicals and materials.
Safety Precautions:
It is important to handle BENZONITRILE, 4-BROMO-2-NITROwith care, as exposure can potentially cause irritation to the eyes, skin, and respiratory tract. It is recommended to avoid inhaling or ingesting it directly, and to use it as per safety guidelines in a controlled environment.

InChI:InChI=1/C7H3BrN2O2/c8-6-2-1-5(4-9)7(3-6)10(11)12/h1-3H

Upstream product

• 99277-71-1 4-bromo-2-nitrobenzoic acid 
• 3460-18-2 1,4-dibromo-2-nitrobenzene 
• 304858-65-9 2-amino-4-bromobenzonitrile 
• 115049-55-3 6-bromo-3-(hydroxyimino)indolin-2-one 
• 6326-79-0 6-bromoisatin 
• 65971-74-6 N-(3-bromophenyl)-2-(hydroxyimino)ethanamide 
• 591-19-5 m-Bromoaniline 
• 544-92-3 copper(I) cyanide 
• 875-51-4 4-Bromo-2-nitroaniline 

Downstream Products

• 99277-71-1 4-bromo-2-nitrobenzoic acid 
• 20776-50-5 2-amino-4-bromobenzoic acid 
• 859184-22-8 2-amino-4-bromo-benzoic acid-(2-chloro-ethyl ester) 
• 1382039-43-1 4-cyano-N-{2-cyano-5-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-phenyl}-2-methyl-benzamide 
• 1630951-35-7 7-(4-(3-cyclopentenylbenzyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one 
• 1630951-20-0 tert-butyl 4-(3-acetamido-4-(acetamidomethyl)phenyl)piperazine-1-carboxylate 
• 1630951-21-1 tert-butyl 4-(3-amino-4-(aminomethyl)phenyl)piperazine-1-carboxylate 
• 1630951-31-3 7-(4-(biphenyl-4-ylmethyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one 
• 1630951-32-4 7-(4-((4'-fluorobiphenyl-4-yl)methyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one 
• 1630951-33-5 7-(4-((5-phenylpyridin-3-yl)methyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one 
• 1630951-34-6 7-(4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one 
• 1027345-15-8 tert-butyl 4-(4-cyano-3-nitrophenyl)piperazine-1-carboxylate 
• 304858-65-9 2-amino-4-bromobenzonitrile 
• 1382041-54-4 2-amino-4-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-benzonitrile 

Relevant academic research and scientific papers

Ag/Cu-mediated decarboxylative cyanation of aryl carboxylic acids with K4Fe(CN)6 under aerobic conditions

A method for facile synthesis of aryl nitriles has been well established via Ag/Cu-mediated decarboxylative cyanation of benzoic acids with K4Fe(CN)6 under aerobic conditions. The approach of using readily accessible aryl carboxylic acids and green K4Fe(CN)6 as starting material provides a feasible alternative to previous cyanation protocols. Control experiments revealed the key role of Cu for the process and excluded the possibility of a radical mechanism for the transformation.

COMPOUND FOR IN VIVO DIAGNOSIS OF A DYSFUNCTION OF ADRENAL GLANDS

The invention concerns a compound having formula (I): wherein R1 represents a radioactive isotope of an element which radioactive isotope is detectable by positron emission tomography (PET) or wherein R1 represents any nonradioactive isotope of said element, R2 represents –CN or –CF3, wherein R3 represents or, wherein * represents C or N and R4 represents one of the moieties of a group consisting of alkyl, alkyl ether, alkyl nitrile, alkyl alcohol, alkyl halide, O-alkyl, S- alkyl, halogen, nitrile, trifluoromethyl, amide, carbonyl pyrrolidine, pyrrolidinyl, 1 amino, aminoalkyl, aminodialkyl, phenyl, substituted phenyl, heterocyclic aromatic, substituted heterocyclic aromatic, saturated heterocyclic, substituted saturated heterocyclic, dioxolanyl, methyldioxolanyl, and dioxanyl.

An electroluminescent compound and an electroluminescent device comprising the same

The present invention relates to organic light emitting compounds represented by chemical formula 1-1 to chemical formula 1-2. An organic electroluminescent device using the same has excellent light emitting efficiency and can be driven at low voltage, thereby having improved power efficiency and long life characteristics.COPYRIGHT KIPO 2015

An electroluminescent compound and an electroluminescent device comprising the same

The present invention relates to organic light emitting compounds represented by chemical formula 1-1 to chemical formula 1-2. An organic electroluminescent device using the same has excellent light emitting efficiency and can be driven at low voltage, thereby having improved power efficiency and long life characteristics.COPYRIGHT KIPO 2015

Synthesis and dual D2 and 5-HT1A receptor binding affinities of 7-piperazinyl and 7-piperidinyl-3,4-dihydroquinazolin-2(1H)-ones

A series of new 7-piperazinyl and 7-piperidinyl-3,4-dihydroquinazolin-2(1H) -ones has been synthesized. The described compounds are structurally related to adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties. Suitably modified aryl bromides were prepared and condensed with tert-butyl piperazine-1-carboxylate to afford the advanced intermediate piperazinyl-3,4-dihydroquinazolin-2(1H)-one. Likewise Suzuki-Miyaura cross-coupling reaction of cyclic vinyl boronate with appropriate aryl bromides rendered piperidinyl-3,4-dihydroquinazolin-2(1H)-one. The reductive amination of the piperazinyl and piperidinyl-3,4- dihydroquinazolin-2(1H)-ones with suitably designed biarylaldehydes accomplished the synthesis of these title compounds. The described compounds were screened for D2 and 5-HT1A receptors binding affinities. The structure-activity relationship studies revealed that cyclopentenylpyridine and cyclopentenylbenzyl groups contribute significantly to the dual D2 and 5-HT1A receptor binding affinities of these compounds.

Dihydroquinone derivatives of piperidine and piperazine

The dihydroquinone derivatives of piperidine and piperazine are 7-piperazinyl and 7-piperadinyl-3,4-dihydroquinazolin-2(1H)-ones that exhibit D2 and 5-HT1A receptor binding affinities, making them suitable for use as the active ingre

Quinazoline derivatives

A compound of the formula (I) or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer mixture thereof has a superior tyrosine-specific protein kinase inhibitory activity and is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of various cancers, psoriasis or diseases caused by arteriosclerosis, and the like.