79780-05-5

Upstream product

• 75-26-3 isopropyl bromide 
• 61717-82-6 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione 
• 131-62-4 1-hydroxy-1,2-benzodioxol-3-(1H)-one 
• 939-48-0 isopropyl benzoate 
• 75-30-9 2-iodo-propane 
• 88-67-5 2-Iodobenzoic acid 
• 67-63-0 isopropyl alcohol 
• 609-67-6 2-Iodobenzoyl chloride 

Downstream Products

• 942-13-2 isopropyl 2-methylbenzoate 
• 1207372-99-3 isopropyl 2-[2-(4-methoxyphenyl)ethynyl]benzoate 
• 32017-66-6 isopropyl 2-benzoylbenzoate 
• 88180-65-8 isopropyl 2-(2-phenylethynyl)benzoate 
• 1408443-65-1 isopropyl 2-(3-hydroxy-3,3-diphenylprop-1-yn-1-yl)benzoate 
• 1408445-62-4 2-(4-methoxyphenyl)-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one 
• 1408445-60-2 (E)-3-phenyl-2-styryl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one 
• 1408445-57-7 3-phenyl-2-(phenylethynyl)-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one 
• 1408444-65-4 2-iodo-3-phenyl-3'H-spiro[indene-1,1'-isobenzofuran]-3'-one 
• 628708-20-3 2-(diphenylphosphanyl)benzoic acid isopropyl ester 
• 674776-90-0 2-iodylbenzoic acid 1-methylethyl ester 
• 939-48-0 isopropyl benzoate 

Relevant academic research and scientific papers

Lipshutz-type bis(amido)argentates for directed: Ortho argentation

Bis(amido)argentate (TMP)2Ag(CN)Li2 (3, TMP-Ag-ate; TMP = 2,2,6,6-tetramethylpiperidido) was designed as a tool for chemoselective aromatic functionalization via unprecedented directed ortho argentation (DoAg). X-Ray crystallographic analysis showed that 3 takes a structure analogous to that of the corresponding Lipshutz cuprate. DoAg with this TMP-Ag-ate afforded multifunctional aromatics in high yields in processes that exhibited high chemoselectivity and compatibility with a wide range of functional groups. These included organometallics- A nd transition metal-susceptible substituents such as methyl ester, aldehyde, vinyl, iodo, (trifluoromethanesulfonyl)oxy and nitro groups. The arylargentates displayed good reactivity with various electrophiles. Chalcogen (S, Se, and Te) installation and azo coupling reactions also proceeded efficiently.

Dual Cobalt and Photoredox Catalysis Enabled Intermolecular Oxidative Hydrofunctionalization

A general protocol has been developed for the Markovnikov-selective intermolecular hydrofunctionalization based on visible-light-mediated Co/Ru dual catalysis. The key feature involves the photochemical oxidation of an organocobalt(III) intermediate deriv

Metal-Free Synthesis of 4-Chloroisocoumarins by TMSCl-Catalyzed NCS-Induced Chlorinative Annulation of 2-Alkynylaryloate Esters

4-Chloroisocoumarins can be conveniently prepared from 2-alkynylaryloate esters via the activation of alkynes by electrophilic chlorine, generated in situ from N-chlorosuccinimide (NCS) in the presence of 10 mol % trimethylsilyl chloride (TMSCl), which leads to 6-endo-dig-selective chlorinative annulation to give the desired products in moderate to quantitative yields. The procedure employs readily available reagents and can be conveniently carried out on a wide scope of substrates under mild conditions (0 °C to rt). Furthermore, the reaction is scalable for gram-scale preparation of 4-chloroisocoumarins. Additionally, 4-bromo- and 4-iodoisocoumarins can be prepared in moderate to good yields by replacing NCS with N-bromosuccinimide (NBS) and N-iodosuccinimide (NIS), respectively.

K2S2O8-promoted [2+2]-cycloaddition of benzyl-2-(3-hydroxypropynyl)-benzoates: A new route to polysubstituted cyclobutanes

An efficient and convenient metal-free [2+2]-cycloaddition of benzyl-2-(3-hydroxypropynyl)-benzoates via allene processes has been developed, which provides impressive access to fused cyclobutanes from easily accessed π-components. This transformation involved the cleavage of two C–O bonds, the formations of two C–O bonds and two C–C bonds and showed some advantages, including mild conditions and wide substrate scope.

Catalyst-Free Synthesis of Borylated Lactones from Esters via Electrophilic Oxyboration

A catalyst-free oxyboration reaction of alkynes is developed. The resulting borylated isocoumarins and 2-pyrones are isolated as boronic acids, pinacolboronate esters, or potassium organotrifluoroborate salts, providing a variety of bench-stable organobor

Facile synthesis of 2-iodo-spiro[indene-1,1′-isobenzofuran]-3′- ones via iodine-promoted cascade cyclization

A novel and efficient synthetic approach to substituted 2-iodo-spiro[indene-1,1′-isobenzofuran]-3′-ones has been developed via an iodine-promoted cascade cyclization of 2-(3-hydroxy-3,3-diarylprop-1-yn- 1-yl)benzoates. This sequential cascade process is concisely conducted at room temperature. Subsequent palladium-catalyzed Sonogashira, Suzuki, and Heck reactions of the resulting iodides proceed smoothly in good yields.

2-Iodoxybenzoic acid-mediated transformation of halogenated hydrocarbon in the presence of tetraethyl ammonium bromide

2-Iodoxybenzoic acid (IBX) has been shown to react with alkyl halides in the presence of tetraethyl ammonium bromide to give 2-iodobenzoate esters. Most of the monohalides and dihalides reacted easily with moderate to good yields. The 2-iodobenzoate ester

Gold-catalyzed C-S bond formation from thiols

ortho-Alkynylbenzoic acid alkyl esters act as alkylating agents of thiol derivatives with PPh3AuCl in combination with AgOTf in 1,2-dichloroethane at 80 °C. The corresponding sulfide compounds are obtained in good to excellent yields.

PREPARATION AND USE OF MAGNESIUM AMIDES

The present application relates to mixed Mg/Li amides of the general formula R1R2N-Mg-NR3R4.zLiY (II) wherein R1, R2, R3, and R4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together, or R3 and R4 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 and at least one of R3 and R4 is other than H; Y is selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; HaIOn, wherein n = 3 or 4 and Hal is selected from Ci, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RxCO2; an alcoholate of the general formula ORx; a thiolate of the general formula SRx; RxP(O)O2; or SCORx; or SCSRx; OnSRx, wherein n = 2 or 3; or NOn, wherein n = 2 or 3; and a derivative thereof; wherein Rx is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, or H; m is O or 1; and z > 1; as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases.

Esters of 2-iodoxybenzoic acid: Hypervalent iodine oxidizing reagents with a pseudobenziodoxole structure

Esters of 2-iodoxybenzoic acid (IBX-esters) were prepared by the hypochlorite oxidation of the corresponding 2-iodobenzoate esters and isolated as chemically stable, microcrystalline products. These hypervalent iodine compounds are potentially valuable ox