799293-87-1

Basic information

• Product Name: Thieno[3,2-c]pyridin-4-amine, 7-bromo-3-(3-chloro-4-fluorophenyl)-
• CAS NO: 799293-87-1
• Molecular Formula: C13H7BrClFN2S
• Molecular Weight: 357.633
• Mol File: 799293-87-1.mol

Chemical Properties

• CAS DataBase Reference: Thieno[3,2-c]pyridin-4-amine, 7-bromo-3-(3-chloro-4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[3,2-c]pyridin-4-amine, 7-bromo-3-(3-chloro-4-fluorophenyl)-(799293-87-1)
• EPA Substance Registry System: Thieno[3,2-c]pyridin-4-amine, 7-bromo-3-(3-chloro-4-fluorophenyl)-(799293-87-1)

Safety Data

• Hazardous Substances Data: 799293-87-1(Hazardous Substances Data)

Upstream product

• 103686-16-4 trans-3-(4-bromothiophen-2-yl)propenoic acid 
• 18791-75-8 4-Bromothiophen-2-aldehyde 
• 799293-81-5 trans-3-(4-bromothiophen-2-yl)-acryloyl azide 
• 799293-85-9 3-bromo-4-amino-[3,2-c]-thienopyridine 
• 799293-83-7 3-bromothieno[3,2-c]pyridin-4(5H)-one 
• 799293-86-0 4-amino-3-(3-chloro-4-fluoro-phenyl)-thieno[3,2-c]pyridine 
• 29064-82-2 3-bromo-4-chloro-[3,2-c]-thienopyridine 

Relevant articles and documents

Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases

A novel class of 3,7-diphenyl-4-amino-thieno and furo[3,2-c]pyridine has been designed based on pharmacophore models of ATP competitive kinase inhibitors. Versatile synthetic methods via double Suzuki coupling to explore SAR have been established and potent inhibitors against angiogenetic targets, VEGFR2, Tie-2, and EphB4, have been successfully discovered.

NOVEL CHEMICAL COMPOUNDS

This invention relates to newly identified compounds for treating and preventing tumors ans cancers, and methods for treating proliferative diseases associated with the imbalance or inappropriate activity of tyrosine kinases implicated in proliferative diseases.