Journal of Medicinal Chemistry p. 3198 - 3211 (2017)
Update date:2022-08-15
Topics: Product Development Enzyme Experimental Arginine Chemical compound Method Selective inhibitor Catalyzes
Muth, Aaron
Subramanian, Venkataraman
Beaumont, Edward
Nagar, Mitesh
Kerry, Philip
McEwan, Paul
Srinath, Hema
Clancy, Kathleen
Parelkar, Sangram
Thompson, Paul R.
Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of multiple sclerosis, rheumatoid arthritis, and breast cancer. To date, no PAD2-selective inhibitor has been developed. Such a compound will be critical for elucidating the
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