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79983-71-4

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79983-71-4 Usage

Description

Different sources of media describe the Description of 79983-71-4 differently. You can refer to the following data:
1. Hexaconazole is a kind of broad-spectrum systemic trazole fungicide. It can be used for the treatment of many kind of fungi diseases caused by ascomycetes, basidiomycetes, and imperfect fungi. It is especially suitable for the treatment of fungi diseases such as powdery mildew, rust, scab, brown blotch and anthracnose caused by ascomycetes and basidiomycetes. In China, India and some other Asian countries, it is mainly used for the control of rice sheath blight. It is applicable to apples, grapes, bananas, vegetables, peanuts, and cereal crops as well as ornament plants. Its mechanism of action is through inhibiting the biosynthesis of ergosterol (a key component of the fungi membrane) of fungi.
2. Hexaconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. It is fungicidal against the powdery mildews B. graminis and S. cucurbitae on cucumber plants in a concentration-dependent manner and is curative against powdery mildew on barley plants when used at a concentration of 6.7 mg/L. It also inhibits growth of R. bataticola and S. rolfsii (ED50s = 6.35 and 1.27 mg/L, respectively). Exogenous application of hexaconazole (15 mg/L) to M. chamomilla plants improves water, proline, and protein contents as well as increases non-enzymatic and enzymatic antioxidant and apigenin-7-glucoside content during a water deficit stress tolerance test. Hexaconazole inhibits the differentiation of mouse embryonic stem cells into cardiomyocytes (EC50 = 16.6 μM). It also induces bone morphological defects in mouse fetuses when administered to pregnant adult females during gestation.

References

https://en.wikipedia.org/wiki/Hexaconazole http://xb-agrochemical.com/3-5-hexaconazole.html/130471 http://krepl.in/wp-content/uploads/2014/10/KRIZOLE-5.pdf

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Different sources of media describe the Uses of 79983-71-4 differently. You can refer to the following data:
1. Hexaconazole is a systematic fungicide of the triazole class. Hexaconazole has a broad spectrum antifungal activity and is commonly used in the control of apple, coffee and peanut diseases.
2. Agricultural fungicide.
3. Hexaconazole is a systemic fungicide used for the control of many fungi, particularly Ascomycetes and Basidiomycetes on a variety of crops. It controls powdery mildews, scabs and rusts of vines, pome fruits, vegetables and major diseases of small grain cereals.

Metabolic pathway

Metabolism of hexaconazole in plants involves primarily oxidation of the alkyl side chain.

Degradation

Hexaconazole is stable for at least 6 years at ambient temperature. It is stable to hydrolysis and photolysis in water.

Check Digit Verification of cas no

The CAS Registry Mumber 79983-71-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,9,8 and 3 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 79983-71:
(7*7)+(6*9)+(5*9)+(4*8)+(3*3)+(2*7)+(1*1)=204
204 % 10 = 4
So 79983-71-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H17Cl2N3O/c1-2-3-6-14(20,8-19-10-17-9-18-19)12-5-4-11(15)7-13(12)16/h4-5,7,9-10,20H,2-3,6,8H2,1H3

79983-71-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name hexaconazole

1.2 Other means of identification

Product number -
Other names Sitara

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:79983-71-4 SDS

79983-71-4Synthetic route

n-butyl magnesium bromide
693-03-8

n-butyl magnesium bromide

1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone
58905-16-1

1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

hexaconazole
79983-71-4

hexaconazole

Conditions
ConditionsYield
Stage #1: 1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone With magnesium bromide ethyl etherate In dichloromethane at 20℃; for 1.5h; Inert atmosphere;
Stage #2: n-butyl magnesium bromide In diethyl ether; dichloromethane at 0 - 20℃; for 12h; Inert atmosphere;
12%
1-(2,4-dichlorophenyl)-2-(4-amino-4H-1,2,4-triazoliumyl)ethanone chloride
118227-30-8

1-(2,4-dichlorophenyl)-2-(4-amino-4H-1,2,4-triazoliumyl)ethanone chloride

hexaconazole
79983-71-4

hexaconazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 20 °C
2.1: magnesium bromide ethyl etherate / dichloromethane / 1.5 h / 20 °C / Inert atmosphere
2.2: 12 h / 0 - 20 °C / Inert atmosphere
View Scheme
2,2',4'-trichloroacetophenone
4252-78-2

2,2',4'-trichloroacetophenone

hexaconazole
79983-71-4

hexaconazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: isopropyl alcohol / 12 h / 80 °C
2.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 20 °C
3.1: magnesium bromide ethyl etherate / dichloromethane / 1.5 h / 20 °C / Inert atmosphere
3.2: 12 h / 0 - 20 °C / Inert atmosphere
View Scheme
copper(II) acetate monohydrate
6046-93-1

copper(II) acetate monohydrate

hexaconazole
79983-71-4

hexaconazole

2C14H17Cl2N3O*Cu(2+)*2C2H3O2(1-)

2C14H17Cl2N3O*Cu(2+)*2C2H3O2(1-)

Conditions
ConditionsYield
In ethanol at 20℃; for 1h;68%
zinc(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

hexaconazole
79983-71-4

hexaconazole

[ZnL34 (DMF)2](NO3)2

[ZnL34 (DMF)2](NO3)2

Conditions
ConditionsYield
In ethanol at 20℃; for 4h;61%
hexaconazole
79983-71-4

hexaconazole

(+)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol

(+)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol

(-)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol

(-)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol

Conditions
ConditionsYield
In hexane; isopropyl alcohol at 20℃; Resolution of racemate; enantioselective reaction;
With chiralpak IC column In hexane; isopropyl alcohol at 20℃; Thermodynamic data; Solvent; Temperature; Resolution of racemate; enantioselective reaction;
1-(6-chloronicotinyl)-2-nitroiminoimidazoline
105827-78-9

1-(6-chloronicotinyl)-2-nitroiminoimidazoline

hexaconazole
79983-71-4

hexaconazole

C14H17Cl2N3O*C9H10ClN5O2

C14H17Cl2N3O*C9H10ClN5O2

Conditions
ConditionsYield
at 100 - 110℃; Inert atmosphere;
1-(6-chloronicotinyl)-2-nitroiminoimidazoline
105827-78-9

1-(6-chloronicotinyl)-2-nitroiminoimidazoline

hexaconazole
79983-71-4

hexaconazole

2C14H17Cl2N3O*C9H10ClN5O2

2C14H17Cl2N3O*C9H10ClN5O2

Conditions
ConditionsYield
at 100 - 110℃; Inert atmosphere;
1-(6-chloronicotinyl)-2-nitroiminoimidazoline
105827-78-9

1-(6-chloronicotinyl)-2-nitroiminoimidazoline

hexaconazole
79983-71-4

hexaconazole

4C14H17Cl2N3O*C9H10ClN5O2

4C14H17Cl2N3O*C9H10ClN5O2

Conditions
ConditionsYield
at 100 - 110℃; Inert atmosphere;
1-(6-chloronicotinyl)-2-nitroiminoimidazoline
105827-78-9

1-(6-chloronicotinyl)-2-nitroiminoimidazoline

hexaconazole
79983-71-4

hexaconazole

6C14H17Cl2N3O*C9H10ClN5O2

6C14H17Cl2N3O*C9H10ClN5O2

Conditions
ConditionsYield
at 100 - 110℃; Inert atmosphere;
1-(6-chloronicotinyl)-2-nitroiminoimidazoline
105827-78-9

1-(6-chloronicotinyl)-2-nitroiminoimidazoline

hexaconazole
79983-71-4

hexaconazole

8C14H17Cl2N3O*C9H10ClN5O2

8C14H17Cl2N3O*C9H10ClN5O2

Conditions
ConditionsYield
at 100 - 110℃; Inert atmosphere;
hexaconazole
79983-71-4

hexaconazole

A

(R)-(+)-α-butyl-α-(2,4-dichlorophenyl)-1,2,4-triazole-1-ethanol
221627-81-2

(R)-(+)-α-butyl-α-(2,4-dichlorophenyl)-1,2,4-triazole-1-ethanol

B

(S)-(-)-α-butyl-α-(2,4-dichlorophenyl)-1,2,4-triazole-1-ethanol
221627-82-3

(S)-(-)-α-butyl-α-(2,4-dichlorophenyl)-1,2,4-triazole-1-ethanol

Conditions
ConditionsYield
With colistin sulfate-based polymer monolithic column In methanol; water at 20℃; Resolution of racemate; Green chemistry; enantioselective reaction;
In methanol; water at 20℃; Reagent/catalyst; Solvent; Resolution of racemate;

79983-71-4Relevant articles and documents

Antifungal Compounds

-

Paragraph 0073-0075, (2018/07/30)

Compounds and compositions having antifungal activity, and methods of using the antifungal compounds and compositions, are described for use in treating fungal infections.

Synergistic Active Compound Combinations Comprising Phenyltriazoles

-

, (2011/07/29)

The present invention relates to novel active compound combinations comprising, firstly, at least one known compound of the formula (I) in which R1 and R2 have the meanings given in the description. and at least one further known active compound from groups (2) to (27) listed in the description, which combinations are highly suitable for controlling animal pests such as insects and unwanted acarids and also phytopathogenic fungi.

Fungicide mixture

-

, (2008/06/13)

A composition comprising effective amounts ofa) a carbamate of the formula I where T is CH or N, n is 0, 1 or 2 and R is halogen, C1-C4-alkyl or C1-C4-haloalkyl, it being possible for the radicals R to be different if n is 2, andc) a compound III selected from the group consisting of the oxime ether carboxylate IIIa, the oxime ether carboxamide IIIb and the methoxyacrylate IIIc and optionally an oxime ether (II) and/or an azole (IV) as defined in the specification which exhibits a synergistically enhanced fungicidal effect is described.

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