79984-70-6

Upstream product

• 952-53-4 1,3-diphenyl-2,3-diazaprop-2-en-1-one 
• 41052-75-9 o-chlorophenylhydrazine hydrochloride 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1595319-69-9 (Z)-N-(3-(2-chlorophenyl)-5-phenyl-1,3,4-oxadiazol-2(3H)-ylidene)-2-methylpropan-2-amine 
• 246848-58-8 1-(2-chlorophenyl)-3-phenyl-1H-1,2,4-triazol-5(4H)-one 
• 65-85-0 benzoic acid 
• 10449-07-7 (2-chlorophenyl)hydrazine 

Relevant academic research and scientific papers

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

Copper(ii)-catalyzed coupling reaction: An efficient and regioselective approach to N′,N′-diaryl acylhydrazines

Using N′-aryl acylhydrazines as aryl donors, a novel copper(ii)-catalyzed homo-coupling reaction of N′-aryl acylhydrazines has been developed for the synthesis of N′,N′-diaryl acylhydrazines. We also provided a complementary procedure for the preparation of unsymmetrical diaryl acylhydrazines via cross-coupling reaction. These protocols featured mild reaction conditions, wide functional group tolerance and highly regioselective products. Control experiments indicated that this kind of coupling reaction might undergo a transient acyl diazene intermediate. This journal is

Pd-catalyzed oxidative annulation of hydrazides with isocyanides: Synthesis of 2-amino-1,3,4-oxadiazoles

An efficient palladium-catalyzed oxidative annulation reaction was developed through sequential isocyanide insertions into N-H and O-H bonds of hydrazides, which provides an efficient access to valuable 2-amino-1,3,4- oxadiazoles and their derivatives.