800401-63-2

Basic information

• Product Name: 5-Chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid
• Synonyms: 5-Chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid;5-Chloro-4-azaindole-2-carboxylic acid, 98%;1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid, 5-chloro-
• CAS NO: 800401-63-2
• Molecular Formula: C₈H₅ClN₂O₂
• Molecular Weight: 196.5905
• EINECS: 936-721-0
• Mol File: 800401-63-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: ca 295℃
• Boiling Point: 467.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.644±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.74±0.30(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 5-Chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid(800401-63-2)
• EPA Substance Registry System: 5-Chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid(800401-63-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 800401-63-2(Hazardous Substances Data)

Usage

Uses

Used for pharmaceutical and cytokine signaling intermediates.

Upstream product

• 28489-45-4 6-methyl-5-nitropyridin-2(1H)-one 
• 800401-61-0 3-(2-chloro-5-nitropyridin-6-yl)-2-oxopropionic acid ethyl ester 
• 22280-60-0 6-chloro-4-methyl-3-nitropyridine 
• 65156-94-7 5-chloro-1H-pyrrolo[3,2-b]pyridine 
• 209286-85-1 5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 1050501-88-6 2-bromo-6-chloro-pyridin-3-amine 
• 127-17-3 2-oxo-propionic acid 
• 800401-62-1 ethyl 5-chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylate 

Relevant articles and documents

INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF

Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and compositions, and methods of using these compounds and compositions.

NOVEL 1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES SUBSTITUTED WITH HETEROCYCLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

The present invention is concerned with novel 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles having formula (I) stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherei

1,3 -DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES SUBSTITUTED WITH HETEROCYCLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

The present invention is concerned with novel 4-substituted 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles having formula (I) tautomers and stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R4, R5, Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.