80041-84-5

Upstream product

• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 1026775-98-3 C₁₀H₉BrO₃ 
• 1026775-99-4 C₁₁H₁₀BrClO₃ 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 55116-09-1 2-bromophenylacetyl chloride 
• 18698-97-0 ortho-bromophenylacetic acid 
• 79-37-8 oxalyl dichloride 
• 80041-81-2 1-(2-bromobenzyl)-3,4-dihydro-6,7-dimethoxyisoquinoline 
• 109558-14-7 β-(3,4-dimethoxyphenyl)ethyl-(2'-bromophenyl)acetamide 

Relevant academic research and scientific papers

Total syntheses of telisatin A, telisatin B and lettowianthine

Treatment of 1-(2-bromoarylmethyl)-3,4-dihydroisoquinolines with oxalyl chloride and triethylamine gave 1-(2-bromophenyl)-5,6-dihydropyrrolo[2,1-a] isoquinoline-2,3-dione derivatives, for example, 1-(2-bromophenyl)-5,6-dihydro- 8,9-dimethoxypyrrolo[2,1-a]

A facile synthesis of telisatin A via microwave-promoted annulation and reformatsky reaction

A facile one-pot synthesis of 2,3-dioxopyrrolo[2,1-a]isoquinolines is reported involving the ring formation of aryl pyruvate derivatives with 3,4-dihydroisoquinolines under basic conditions and utilizing the Reformatsky reaction. Using microwave irradiation, the required compounds were obtained in moderate to good yields. Georg Thieme Verlag Stuttgart.

Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines

Pyrrolo-benzylisoquinolines were prepared as target compounds and their antiplatelet aggregation activity, adreno-receptor affinity, and cytotoxicity were screened. Compounds 1d-9d showed specific antiplatelet aggregation activity induced by arachidonic acid and collagen. Among them, 8d and 9d exhibited better activity than the reference drug, aspirin and 9d also showed inhibition of platelet aggregation by all four inducers.