80054-80-4

Usage

Type of compound

Chlorinated aromatic compound

Functional group

Trifluoroethoxy group attached to the benzene ring

Common uses

Intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals
Reagent in organic synthesis
Solvent in various industrial processes
Applications in the field of liquid crystals
Precursor in the production of dyes and pigments

Hazardous substance

Yes, should be handled and disposed of properly to minimize environmental and health impacts.

InChI:InChI=1/C8H6ClF3O/c9-6-1-3-7(4-2-6)13-5-8(10,11)12/h1-4H,5H2

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 122-88-3 4-Chlorophenoxyacetic acid 
• 1680206-12-5 Grushin’s reagent 
• 106-39-8 bromochlorobenzene 
• 106-46-7 para-dichlorobenzene 
• 433-06-7 2,2,2-Trifluoroethyl p-toluenesulfonate 
• 106-48-9 4-chloro-phenol 
• 23199-56-6 2,2,2-trifluoroethyltrichloromethanesulfonate 
• 70384-51-9 Tris(3,6-dioxaheptyl)amine 
• 120-82-1 1,2,4-Trichlorobenzene 
• 371-67-5 2,2,2-trifluorodiazoethane 

Relevant academic research and scientific papers

Silver-Catalyzed Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

The silver-catalyzed decarboxylative trifluoromethylation of aliphatic carboxylic acids is described. With AgNO3 as the catalyst and K2S2O8 as the oxidant, the reactions of aliphatic carboxylic acids with (bpy)C

A practical ligand-free copper(I) bromide-catalyzed fluoroalkoxylation of unactivated aryl bromides

An efficient ligand-free fluoroalkoxylation of unactivated aryl bromides has been developed, with special attention focused on practicability of the reaction. Without precious metal and organic ligand, the reaction was carried out under the catalytic system of inexpensive copper(I) bromide as a catalyst, N,N-dimethyl formamide as a cocatalyst, and the corresponding stoichiometric sodium fluoroalkoxide as a nucleophilic reagent. The facile approach avoids the drawbacks associated with cost, separation and pollution of ligand to enable sustainable access to aryl fluoroalkyl ethers from readily available bromoarenes.

Processes for preparing pentafluoroethoxy- and pentafluoroethylthiobenzene drivatives

A process for the preparation of (pentafluoroethoxy)- and (pentafluoroethylthio)benzene derivatives either from phenol, thiophenol or from halobenzene. A halobenzene is reacted with trifluoroethanol or a phenol or a thiophenol is reacted with a compound of the formula CF3 --CH2 --O--R'. The product is chlorinated and the chlorinated product is fluorinated in liquid hydrofluoric acid in the presence of a Lewis acid. The compounds obtained by the process of the present invention are used as synthesis intermediates in the phytosanitary, pharmaceutical and veterinary industries, and are used in lubricants.

Process for preparing trifluoroethoxybenzene or trifluoroethylthiobenzene

A process for preparing substituted or unsubstituted trifluoroethoxy- or trifluoroethylthiobenzenes by reaction of a phenol or thiophenol, both of which may be substituted or unsubstituted, with a compound of the formula CF3 --CH2 --O--R', where R' is a moiety selected from the group consisting of trifluoroacetyl, methanesulfonyl, paratoluenesulfonyl, trichloromethanesulfonyl and chlorosulfonyl, in the presence of a strong alkaline base and a complexing agent of the formula: wherein n is an integer from 0 to 10 (0 is less than or equal to n is less than or equal to 10), R1, R2, R3 and R4, which may be identical or different, are selected from the group consisting of a hydrogen atom and an alkyl moiety having from 1 to 4 carbon atoms, and R5 denotes an alkyl or cycloalkyl moiety having from 1 to 12 carbon atoms, a phenyl moiety or a moiety of the formula: --Cm H2m --C6 H5 or Cm H(2m+1) --C6 H4 --, where m is from 1 to 12.

Acid-Catalyzed Reaction of 2,2,2-Trifluorodiazoethane for Analysis of Functional Groups by 19F Nuclear Magnetic Resonance Spectrometry

The acid-catalyzed reactions of trifluorodiazoethane with alcohols, phenols, thiols, and carboxylic acids are reported.The yield data for these trifluoroethyl derivatives suggest a simple, and in many cases, quantitative method for introduction of a fluorine tagging group.The 19F chemical shifts indicate that most functional groups (e.g., phenols, alcohols, etc.) have fairly well resolved chemical shifts regions.In addition, paramagnetic shift reagents have been utilized to selectively differentiate carboxylic acids from other active hydrogen functional groups.