80129-86-8Relevant academic research and scientific papers
Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents
Lang, Xuliang,Li, Lulu,Chen, Yuzong,Sun, Qinsheng,Wu, Qin,Liu, Feng,Tan, Chunyan,Liu, Hongxia,Gao, Chunmei,Jiang, Yuyang
, p. 4170 - 4177 (2013/07/27)
Acridine derivatives have been explored as DNA-binding anticancer agents. Some derivatives show undesired pharmacokinetic properties and new derivatives need to be explored. In this work, a series of novel acridine analogues were synthesized by modifying previously unexplored linkers between the acridine and benzene groups and their antiproliferative activity and the DNA-binding ability were evaluated. Among these derivatives, compound 5c demonstrated DNA-binding capability and topoisomerase I inhibitory activity. In K562 cell lines, 5c induced apoptosis through mitochondria-dependent intrinsic pathways. These data suggested that compound 5c and other acridine derivatives with modified linkers between the acridine and benzene groups might be potent DNA-binding agents.
Selective N-alkylation of arylamines with alkyl chloride in ionic liquids: Scope and applications
Monopoli, Antonio,Cotugno, Pietro,Cortese, Marina,Calvano, Cosima Damiana,Ciminale, Francesco,Nacci, Angelo
supporting information; experimental part, p. 3105 - 3111 (2012/06/30)
An efficient N-selective alkylation of primary aromatic amines in molten quaternary ammonium salts, as the solvent, under relatively mild and base-free conditions is presented. On the basis of the Kamlet-Taft parameters and the nucleophilicity of the IL (ionic liquid) anions, the influence of the ionic liquid was evaluated. This protocol was validated on a larger multigram scale and with the syntheses of bioactive heterocycles (e.g., 1,4-benzothiazine and quinoxalines) and new efficient MALDI matrixes. Copyright
ETUDE COMPARATIVE DE LA REACTIVITE DES ACRIDANONES, DES AMINOACRIDINES ET DES THIOACRIDANONES VIS-A-VIS DES AGENTS D'ALKYLATION DANS LES CONDITIONS DE LA CATALYSE PAR TRANSFERT DE PHASE
Galy, J. P.,Vincent, E. J.,Galy, A. M.,Barbe, J.,Elguero, J.
, p. 947 - 954 (2007/10/02)
This paper describes the results obtained in the alkylation of thioacridanone under phase transfer catalysis conditions.Nine different alkylating agents have been used and in all the cases the thioether was the sole product obtained.Proton and carbon-13 n.m.r. study of the different compounds has been carried out, giving an useful criteria to differentiate thioethers and thioacridanones.The HSAB principle has been used to discuss the relative amounts of 9- and 10- substituted isomers obtained from acridanones, aminoacridines and thioacridanones using different alkylating and acylating agents.
