80145-44-4

Upstream product

• 186581-53-3 diazomethane 
• 98-01-1 furfural 
• 110-00-9 furan 
• 108-24-7 acetic anhydride 
• 917-64-6 methyl magnesium iodide 
• 72667-24-4 Brenzschleimsaeurenitril 
• 64-19-7 acetic acid 
• 32488-17-8 N,N-diethyl furan 2-carboxamide 
• 917-54-4 methyllithium 
• 62889-08-1 1-(2-furyl)-1-(trimethylsilyloxy)ethylene 
• 136590-93-7 (1-(furan-2-yl)ethoxy)trimethylsilane 
• 51583-40-5 2-(trimethylstannyl)furan 
• 75-36-5 acetyl chloride 
• 74-88-4 methyl iodide 

Downstream Products

• 17275-73-9 1-phenyl-2-furylpropan-2-ol 
• 83393-60-6 3-(2-(furan-2-yl)-2-oxoethyl)-3-hydroxyindolin-2-one 
• 91962-71-9 rac-1-furan-2-yl-1-phenyl-ethanol 
• 78597-06-5 1-(2-furyl)ethanone thiosemicarbazone 
• 84756-52-5 1-(1-butyl-1H-pyrrol-2-yl)ethanone 
• 36983-35-4 ethyl 4-(furan-2-yl)-2,4-dioxobutyrate 
• 164173-94-8 1,4-bis<1,5-(di-2-furyl)-1,5-dioxopentan-3-yl>benzene 
• 65927-49-3 o--phenol 
• 154258-82-9 3-(4-fluorophenyl)-1H-pyrazole 
• 90846-70-1 D_g-threo-2-acetoxy-3-(toluene-4-sulfonyloxy)-butane 
• 90846-70-1 (2R,3S)-3-(tosyloxy)butan-2-yl acetate 
• 6137-68-4 2-(prop-1-en-2-yl)furan 
• 80521-10-4 (tosyloxy)methyl 2-furanyl ketone 
• 769140-93-4 (5S)-3-methyl-5-(2-furyl)-2-oxazolidinone 

Relevant academic research and scientific papers

Characteristic flavor formation of thermally processed N-(1-deoxy-α-D-ribulos-1-yl)-glycine: Decisive role of additional amino acids and promotional effect of glyoxal

The role of amino acids and α-dicarbonyls in the flavor formation of Amadori rearrangement product (ARP) during thermal processing was investigated. Comparisons of the volatile compounds and their concentrations when N-(1-deoxy-α-D-ribulos-1-yl)-glycine r

The dehydrogenative oxidation of aryl methanols using an oxygen bridged [Cu-O-Se] bimetallic catalyst

Herein, we report a new protocol for the dehydrogenative oxidation of aryl methanols using the cheap and commercially available catalyst CuSeO3·2H2O. Oxygen-bridged [Cu-O-Se] bimetallic catalysts are not only less expensive than other catalysts used for the dehydrogenative oxidation of aryl alcohols, but they are also effective under mild conditions and at low concentrations. The title reaction proceeds with a variety of aromatic and heteroaromatic methanol examples, obtaining the corresponding carbonyls in high yields. This is the first example using an oxygen-bridged copper-based bimetallic catalyst [Cu-O-Se] for dehydrogenative benzylic oxidation. Computational DFT studies reveal simultaneous H-transfer and Cu-O bond breaking, with a transition-state barrier height of 29.3 kcal mol?1

Visible light mediated selective oxidation of alcohols and oxidative dehydrogenation of N-heterocycles using scalable and reusable La-doped NiWO4nanoparticles

Visible light-mediated selective and efficient oxidation of various primary/secondary benzyl alcohols to aldehydes/ketones and oxidative dehydrogenation (ODH) of partially saturated heterocycles using a scalable and reusable heterogeneous photoredox catalyst in aqueous medium are described. A systematic study led to a selective synthesis of aldehydes under an argon atmosphere while the ODH of partially saturated heterocycles under an oxygen atmosphere resulted in very good to excellent yields. The methodology is atom economical and exhibits excellent tolerance towards various functional groups, and broad substrate scope. Furthermore, a one-pot procedure was developed for the sequential oxidation of benzyl alcohols and heteroaryl carbinols followed by the Pictet-Spengler cyclization and then aromatization to obtain the β-carbolines in high isolated yields. This methodology was found to be suitable for scale up and reusability. To the best of our knowledge, this is the first report on the oxidation of structurally diverse aryl carbinols and ODH of partially saturated N-heterocycles using a recyclable and heterogeneous photoredox catalyst under environmentally friendly conditions.

Preparation and Degradation of Rhodium and Iridium Diolefin Catalysts for the Acceptorless and Base-Free Dehydrogenation of Secondary Alcohols

Rhodium and iridium diolefin catalysts for the acceptorless and base-free dehydrogenation of secondary alcohols have been prepared, and their degradation has been investigated, during the study of the reactivity of the dimers [M(μ-Cl)(I4-C8H12)]2 (M = Rh (1), Ir (2)) and [M(μ-OH)(I4-C8H12)]2 (M = Rh (3), Ir (4)) with 1,3-bis(6′-methyl-2′-pyridylimino)isoindoline (HBMePHI). Complex 1 reacts with HBMePHI, in dichloromethane, to afford equilibrium mixtures of 1, the mononuclear derivative RhCl(I4-C8H12){κ1-Npy-(HBMePHI)} (5), and the binuclear species [RhCl(I4-C8H12)]2{μ-Npy,Npy-(HBMePHI)} (6). Under the same conditions, complex 2 affords the iridium counterparts IrCl(I4-C8H12){κ1-Npy-(HBMePHI)} (7) and [IrCl(I4-C8H12)]2{μ-Npy,Npy-(HBMePHI)} (8). In contrast to chloride, one of the hydroxide groups of 3 and 4 promotes the deprotonation of HBMePHI to give [M(I4-C8H12)]2(μ-OH){μ-Npy,Niso-(BMePHI)} (M = Rh (9), Ir (10)), which are efficient precatalysts for the acceptorless and base-free dehydrogenation of secondary alcohols. In the presence of KOtBu, the [BMePHI]- ligand undergoes three different degradations: Alcoholysis of an exocyclic isoindoline-N double bond, alcoholysis of a pyridyl-N bond, and opening of the five-membered ring of the isoindoline core.

Preparation method of 2-acetylfuran

The invention discloses a preparation method of 2-acetylfuran, which comprises the following steps: taking furfural as a raw material, carrying out Grignard reaction to obtain furfuryl alcohol, and carrying out oxidation reaction on furfuryl alcohol in the presence of a catalyst in an oxygen-containing atmosphere to obtain 2-acetylfuran, wherein the catalyst is a 4-hydroxy-2, 2, 6, 6-tetramethylpyridine oxide (Temp) and potassium bromide. The method is simple in process, simple in catalyst and suitable for large-scale industrial production, the stability meets the market requirements of products, the product cost is lower than that of existing industrial production, and the product quality is better.

CtD strategy to construct stereochemically complex and structurally diverse compounds from griseofulvin

The Complexity to Diversity (CtD) strategy, a strategy for the synthesis of stereochemically complex and structurally diverse small molecules from natural products using ring-distortion reactions, was applied in the synthesis of a 47-member compound collection from the natural product griseofulvin. A Tsuji-Trost allylation and oxa-Michael cyclization tandem reaction was used for the first time in the CtD strategy to generate complex ring fused compounds.

Hydration of Alkynes to Ketones with an Efficient and Practical Polyoxomolybdate-based Cobalt Catalyst

Hydration of alkynes to ketones is one of the most atom economical and universal methods for the synthesis of carbonyl compounds. However, the basic reaction usually requires organic ligand catalysts or harsh reaction conditions to insert oxygen into the C≡C bond. Here, we report an inorganic ligand supported cobalt (III) catalyst, (NH4)3[CoMo6O18(OH)6], which is supported by a central cobalt (III) mononucleus and a ring-shaped pure inorganic ligand composed of six MoVIO6 octahedrons to avoid the disadvantages of expensive and unrecyclable organic ligand catalysts or noble metal catalysts. Under mild conditions, the cobalt (III) catalyst can be used for the hydration of alkynes to ketones. The catalyst is non-toxic, green, and environment friendly. The catalyst can be recycled at least six times with high activity. According to control experiments, a reasonable mechanism is provided.

PhSe(O)OH/NHPI-catalyzed oxidative deoximation reaction using air as oxidant

A novel oxidative deoximation method was developed in this article. Compared with the reported organoselenium-catalyzed oxidative deoximation reaction, this reaction employed N-hydroxyphthalimide (NHPI) as the co-catalyst, so that the oxidative deoximation reaction could utilize air as oxidant in the green DMC solvent under mild reaction conditions. Control experiments and X-ray photoelectron spectroscopy (XPS) analysis results indicated that NHPI was essential for activating the catalytic organoselenium species. It could accelerate the activation of molecular oxygen in air to promote the reaction process. The reaction can avoid metal residues in product and is of potential application values in pharmaceutical industry due to the transition metal-free process.

Selective oxidation of alkenes to carbonyls under mild conditions

Herein, a practical and sustainable method for the synthesis of aldehydes, ketones, and carboxylic acids from an inexpensive olefinic feedstock is described. This transformation features very sustainable and mild conditions and utilizes commercially available and inexpensive tetrahydrofuran as the additive, molecular oxygen as the sole oxidant and water as the solvent. A wide range of substituted alkenes were found to be compatible, providing the corresponding carbonyl compounds in moderate-to-good yields. The control experiments demonstrated that a radical mechanism is responsible for the oxidation reaction.

Aryl aldiketone and synthesis method thereof

The invention discloses an aryl aldehyde ketone and a synthesis method thereof, wherein an aryl aldehyde is synthesized from cheap olefin as a raw material. A commercially available inexpensive olefin is used as a raw material, ether is used as an additive, molecular oxygen serves as a sole oxidizing agent, water is used as a solvent, and the aldehyde and ketone are synthesized by column chromatography under a photocatalytic condition. The invention has the advantages of mild reaction conditions, green and environmental protection, simple experimental operation, good reaction selectivity, high product yield and the like.