801983-46-0Relevant academic research and scientific papers
Halogen-magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids
Kopp, Felix,Wunderlich, Stefan,Knochel, Paul
, p. 2075 - 2077 (2007)
The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl·LiCl; the resulting double-magnesiated species react with a variety of electrophiles in up to 97% yield. The Royal Society of Chemistry.
