80221-77-8

Basic information

• Product Name: methyl 6-methyl-2-phenyl-4-quinolinecarboxylate
• Synonyms: methyl 6-methyl-2-phenyl-4-quinolinecarboxylate
• CAS NO: 80221-77-8
• Molecular Formula: C₁₈H₁₅NO₂
• Molecular Weight: 277.3172
• Mol File: 80221-77-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 6-methyl-2-phenyl-4-quinolinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 6-methyl-2-phenyl-4-quinolinecarboxylate(80221-77-8)
• EPA Substance Registry System: methyl 6-methyl-2-phenyl-4-quinolinecarboxylate(80221-77-8)

Safety Data

• Hazardous Substances Data: 80221-77-8(Hazardous Substances Data)

Upstream product

• 107969-78-8 methyl benzylidenepyruvate 
• 106-49-0 p-toluidine 
• 67-56-1 methanol 
• 98-80-6 phenylboronic acid 
• 608-05-9 5-methyl-indole-2,3-dione 
• 547-64-8 methyl lactate 
• 100-52-7 benzaldehyde 
• 600-22-6 pyruvic acid methyl ester 
• 1613-92-9 (E)-N-benzylidene-4-toluidine 
• 292638-85-8 acrylic acid methyl ester 
• 60538-98-9 6-methyl-2-phenylquinoline-4-carboxylic acid 

Relevant articles and documents

Palladium-Catalyzed Three-Component Cascade Reaction of Nitriles: Synthesis of 2-Arylquinoline-4-carboxylates

A new method for converting easy availability starting materials 2-(2-oxoindolin-3-yl)acetonitrile, arylboronic acids, and alcohols into 2-arylquinoline-4-carboxylates is reported. The procedure involves a three-component addition/ring expansion/esterification reaction in the presence of Pd(II) catalyst with high functional group tolerance under mild conditions. In addition, the photophysical properties of the resulting product were investigated and exhibited excellent polarity-sensitive fluorescence properties and AIE property.

Triple zirconocene/br?nsted acid/CuO cooperative and relay catalysis system for tandem Mannich addition/C-C formative cyclization/oxidation

A new triple cooperative and relay catalysis system featuring the Mannich addition followed by C-C construction and oxydehydrogenation is described. The zirconocene dichloride and trimellitic acid synergic catalysis triggered the Mannich addition and C-C bond construction reactions, while CuO allowed relay catalysis for oxydehydrogenation. This novel strategy demonstrated superior activity for the synthesis of substituted quinolines from commercially available anilines, aldehydes and ketones. The corresponding substituted quinolines were synthesized with 32 examples in 90-96% yields under mild reaction conditions. A novel zirconocene-Br?nsted acid complex, generated in situ and acting as an active catalyst, was validated from the mechanistic studies.

THE REACTION OF IMIDOYL RADICALS WITH MULTIPLE CARBON-CARBON BONDS

A general view on the reaction between imidoyl radicals and carbon-carbon double or triple bonds is given; the synthesis of substituted quinolines starting from imines and alkenes is described, pointing out the differences with respect to the analogous reaction performed with alkynes.