methyl 6-methyl-2-phenyl-4-quinolinecarboxylate

Base Information

Chemical Name:methyl 6-methyl-2-phenyl-4-quinolinecarboxylate
CAS No.:80221-77-8
Molecular Formula:C18H15NO2
Molecular Weight:277.31700
Hs Code.:
Mol file:80221-77-8.mol

Synonyms:6-Methyl-4-methoxycarbonyl-2-phenylquinoline;6-Methyl-2-phenyl-quinoline-4-carboxylic acid methyl ester;6-Methyl-2-phenyl-chinolin-4-carbonsaeure-methylester;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 6-methyl-2-phenyl-4-quinolinecarboxylate

Chemical Property:

PSA：39.19000
LogP:3.99680

Purity/Quality:

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Technology Process of methyl 6-methyl-2-phenyl-4-quinolinecarboxylate

There total 8 articles about methyl 6-methyl-2-phenyl-4-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 600-22-6
pyruvic acid methyl ester

: 100-52-7
benzaldehyde

: 106-49-0,12221-03-3
p-toluidine

: 80221-77-8
methyl 6-methyl-2-phenylquinoline-4-carboxylate

Guidance literature:: With zirconocene dichloride; 1,2,4-benzene tricarboxylic acid; copper(II) oxide; In water; isopropyl alcohol; at 60 ℃; for 2h; Green chemistry;
DOI:10.1039/c7ra00870h

Reference yield: 78.0%

: 547-64-8,2155-30-8
methyl lactate

: 100-52-7
benzaldehyde

: 106-49-0,12221-03-3
p-toluidine

: 80221-77-8
methyl 6-methyl-2-phenylquinoline-4-carboxylate

Guidance literature:: With iron(III) chloride; at 110 ℃; for 12h; Green chemistry;
DOI:10.1039/d0gc00738b

Reference yield: 41.0%

: 67-56-1
methanol

: 2-(5-methyl-2-oxoindolin-3-yl)acetonitrile

: 98-80-6
phenylboronic acid

: 80221-77-8
methyl 6-methyl-2-phenylquinoline-4-carboxylate

Guidance literature:: With [2,2]bipyridinyl; palladium(II) trifluoroacetate; benzenesulfonic acid; at 80 ℃; for 24h; Schlenk technique; Sealed tube;
DOI:10.1021/acs.orglett.1c02962