80244-95-7

Upstream product

• 98-88-4 benzoyl chloride 
• 37077-81-9 1,2-isopropylidene-α-D-ribofuranose 
• 13035-61-5 1,2,3,5-tetraacetylribose 
• 6022-96-4 5-O-benzoyl-α-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 6698-46-0 5-O-benzoyl-1,2-O-isopropylidene-α-D-ribofuranos-3-ulose 

Downstream Products

• 6612-91-5 ((3aR,5R,65,6aR)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate 
• 37077-81-9 1,2-isopropylidene-α-D-ribofuranose 
• 917110-29-3 1-(3-deoxy-3-fluoro-β-D-lyxofuranosyl)thymine 
• 917110-29-3 3'-deoxy-3'-fluoro-5-methyl-1-β-D-xylofuranosyluracil 
• 158980-88-2 1-(2-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-β-D-xylofuranosyl)thymine 
• 125291-16-9 N2-acetyl-9-(5-O-benzoyl-2,3-dideoxy-3-fluoro-β-D-xylofuranosyl)guanine 
• 125291-15-8 9-(3-deoxy-3-fluoro-β-D-xylofuranosyl)guanine 

Relevant academic research and scientific papers

1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-xylofuranose. A versatile precursor for the synthesis of 3-deoxy-3-fluoro-β-D-xylofuranosyl nucleosides as potential antiviral agents

The title compound has been synthesized from D-xylose for use in the preparation of 3-deoxy-3-fluoro-β-D-xylofuranosyl nucleoside analogues and their 2-deoxy derivatives, as exemplified in the guanine and thymine series. The title compound has been synthe

Total synthesis of mycalisine B

The first total synthesis of the marine nucleoside Mycalisine B-a naturally occurring and structurally distinct 4,5-unsaturated 7-deazapurine nucleoside-has been accomplished in 10 linear steps with 27.5% overall yield from commercially available 1,2,3,5-tetra-O-acetyl-ribose and tetracyanoethylene. Key steps of the approach include: (1) I2 catalyzed acetonide formation from 1,2,3,5-tetra-O-acetylribose and acetone at large scale; (2) Vorbrüggen glycosylation using N4-benzoyl-5-cyano-6-bromo-7H-pyrrolo[2,3-d]pyrimidine as a nucleobase to avoid formation of N-3 isomer; (3) mild and scalable reaction conditions.