80282-49-1

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 69-72-7 salicylic acid 
• 288-32-4 1H-imidazole 
• 1441-87-8 salicyloyl chloride 

Downstream Products

• 138206-46-9 (E)-1-<1-(2-Hydroxyphenyl)-2-(methylthio)ethenyl>-1H-imidazole 
• 130773-02-3 (E)-1-[2-methylthio-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole hydrochloride 
• 1092940-82-3 2-azido-5'-O-[N-(2-hydroxybenzoyl)sulfamoyl]-2',3'-O-isopropylideneadenosine triethylammonium 
• 80282-50-4 ethyl thiosalicylate 
• 1469-94-9 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione 
• 67410-90-6 2-hydroxy-N-(7-oxa-3-thia-1-aza-spiro[5.5]undec-1-en-2-yl)-benzamide 

Relevant academic research and scientific papers

Actinide sequestration using self-assembled monolayers on mesoporous supports

Surfactant templated synthesis of mesoporous ceramics provides a versatile foundation upon which to create high efficiency environmental sorbents. These nanoporous ceramic oxides condense a huge amount of surface area into a very small volume. The ceramic

Thieme Chemistry Journals Awardees - Where Are They Now? Chiral Sulfinamide Ligands and Pd-Catalyzed Asymmetric Allylic Alkylations of Ethyl 2-Fluoroacetoacetate

New chiral sulfinamide ligands made from salicylic acids and chiral tert -butanesulfinamide was utilized in Pd-catalyzed asymmetric allylic substitutions of ethyl 2-fluoroacetoacetate, which afforded the fluorinated allyl products with up to 98% yield, 94% ee, and 2.2:1 dr. Both sulfoxide and hydroxyl group on the sulfanilamide ligands are crucial for enantiocontrol in the Pd-catalyzed allylic alkylations of ethyl 2-fluoroacetoacetate.

Study of the Reaction of Hydroxybenzoyl Chlorides and Their Derivatives with Imidazole

The reaction of hydroxybenzoyl chlorides with imidazole was studied on an example of the Schotten-Baumann reaction of salicyloyl and acetylsalicyloyl chlorides with imidazole, which, according to soe published data, can take two different ways. It was sho

Neticonazole hydrochloride preparation method

The invention discloses a neticonazole hydrochloride preparation method, which comprises: carrying out an acylation reaction on imidazole and o-hydroxybenzoic acid, carrying out a wittig reaction on the product of the acylation reaction and 1-halogenated dimethyl sulfide, carrying out a reaction on the product of the wittig reaction and 1-halogenated pentane in an inorganic alkali, and salifying the product of the reaction and hydrochloric acid to obtain the neticonazole hydrochloride. According to the present invention, the method can avoid the use of the methanethiol and thionyl chloride, has characteristics of environmental protection, mild reaction condition, simple operation, simple post-treatment and high product purity, and is suitable for industrial production.

Chiral sulfinamide ligand as well as preparation method and application of chiral sulfinamide ligand

The invention relates to a chiral sulfinamide ligand as well as a preparation method and application of the chiral sulfinamide ligand. The ligand is further applied to asymmetric allylation reaction catalyzed by metal palladium. In dried tetrahydrofuran,

Organo-functionalized trimethoxysilanes featuring thioester linkage: Synthetic and UV–Vis spectral investigations

The current work reveals a series of new organo-functionalized trimethoxysilanes (OfTMS) linked via a 3C tether to the thioester group along with the inclusion of versatile aromatic and heteroaromatic sequences. The synthetic procedure implicates the one-pot thioesterification reaction of the precursor carboxylic acids (1a-r) with 3-mercaptopropyltrimethoxysilane (MPTMS), stimulated by 1,1′-carbonyldiimidazole (CDI). The OfTMS have been attentively characterized by elemental analysis, infrared and [1H, 13C] NMR spectroscopic techniques. The UV–Vis absorption behaviour demonstrates that the alkoxysilanes possess high sensitivity to the changes caused in the environment on account of different substitutions. Furthermore, the solvent effect on the absorption spectra has been scrutinized and quantified using the Kamlet-Taft approach. Importantly, the fabricated stable alkoxysilanes can be aspired for advance applications in the field of material science.

Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5′-O-[N-(salicyl)sulfamoyl]adenosine: Antibacterial nucleosides effective against Mycobacterium tuberculosis

The synthesis, biochemical, and biological evaluation of a systematic series of 2-triazole derivatives of 5′-O-[N-(salicyl)sulfamoyl]adenosine (Sal-AMS) are described as inhibitors of aryl acid adenylating enzymes (AAAE) involved in siderophore biosynthesis by Mycobacterium tuberculosis. Structure-activity relationships revealed a remarkable ability to tolerate a wide range of substituents at the 4-position of the triazole moiety, and a majority of the compounds possessed subnanomolar apparent inhibition constants. However, the in vitro potency did not always translate into whole cell biological activity against M. tuberculosis, suggesting that intrinsic resistance plays an important role in the observed activities. Additionally, the well-known valence tautomerism between 2-azidopurines and their fused tetrazole counterparts led to an unexpected facile acylation of the purine N-6 amino group.

A CONVENIENT ONE-POT PROCEDURE FOR SYNTHESIS OF THIOL ESTERS USING MAGNESIUM ION AS A CATALYST

Various thiol esters (R1COSR2) were prepared in high yields by treatment of 1-acylimidazole with thiols in the presence of a catalytic amount of Mg(OEt)2.Malonic half-thiol esters 1OCOCH(R3)COSR2> were also prepared in good yields by treating magnesium monoalkyl malonate 1OCOCH(R3)COOMg0.5> with carbonyl-1,1'-diimidazole followed by addition of thiols.