130773-02-3 Usage
Uses
Used in Pharmaceutical Industry:
1-[2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole hydrochloride is used as an antifungal agent for the treatment of various skin infections, such as tinea pedis, tinea corporis, tinea cruris, intertrigo-type candidiasis, erosio interdigitalis, and tinea versicolor. Its potent activity against a wide range of fungi and some Gram-positive bacteria makes it a valuable asset in the management of skin infections.
Used in Antifungal Treatments:
Neticonazole hydrochloride is used as a therapeutic agent for combating fungal infections, particularly those caused by Candida species. Its effectiveness in treating various skin conditions and its ability to modulate fungal growth make it a preferred choice for patients suffering from such infections.
Used in Research and Development:
1-[2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole hydrochloride is also utilized in the research and development of new antifungal drugs and therapies. Its potent activity against a variety of fungi and bacteria makes it a promising candidate for further study and potential development of novel treatments for fungal and bacterial infections.
Brand Name:
The brand name for 1-[2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole hydrochloride is Atolant, which is available in the form of a one percent cream for once-daily application.
Originator
SS Pharmaceutical (Japan
)
Hazard
Moderately toxic by ingestion.
Check Digit Verification of cas no
The CAS Registry Mumber 130773-02-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,7,7 and 3 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 130773-02:
(8*1)+(7*3)+(6*0)+(5*7)+(4*7)+(3*3)+(2*0)+(1*2)=103
103 % 10 = 3
So 130773-02-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H22N2OS.ClH/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19;/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3;1H/b16-13+;
130773-02-3Relevant academic research and scientific papers
Neticonazole hydrochloride preparation method
-
, (2018/04/01)
The invention discloses a neticonazole hydrochloride preparation method, which comprises: carrying out an acylation reaction on imidazole and o-hydroxybenzoic acid, carrying out a wittig reaction on the product of the acylation reaction and 1-halogenated dimethyl sulfide, carrying out a reaction on the product of the wittig reaction and 1-halogenated pentane in an inorganic alkali, and salifying the product of the reaction and hydrochloric acid to obtain the neticonazole hydrochloride. According to the present invention, the method can avoid the use of the methanethiol and thionyl chloride, has characteristics of environmental protection, mild reaction condition, simple operation, simple post-treatment and high product purity, and is suitable for industrial production.
