80304-39-8

Usage

Structure

Ethyl ester derivative of 1H-imidazole-4-carboxylic acid with a phenyl group attached at the 5-position

Potential applications

Drug synthesis, medicinal chemistry, anti-inflammatory, antifungal, and antitumor agent, building block for the synthesis of various organic compounds for pharmaceutical and agricultural applications

Contains an imidazole ring

A common pharmacophore in many biologically active compounds.

Upstream product

• 64-18-6 formic acid 
• 41381-97-9 ethyl 2-chloro-3-oxo-3-phenylpropionate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 77287-34-4 formamide 
• 50-00-0 formaldehyd 
• 3885-45-8 ethyl 2,3-dioxo-3-phenylpropanoate 

Downstream Products

• 959007-51-3 2-bromo-4-phenyl-1⁽³⁾H-imidazole 
• 80304-38-7 4-hydroxymethyl-5-phenyl-imidazole 
• 80304-40-1 4-hydroxymethyl-5-phenyl-imidazole hydrochloride 
• 655253-58-0 1-methyl-4-phenyl-1H-imidazol-5-carboxylic acid 
• 802052-58-0 4-phenyl-1H-imidazol-5-ylcarboxylic acid 

Relevant academic research and scientific papers

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus

We previously reported potent hit compound 4 inhibiting the wild-type influenza A virus A/HK/68 (H3N2) and A/M2-S31N mutant viruses A/WS/33 (H1N1), with its latter activity quite weak. To further increase its potency, a structure-activity relationship study of a series of imidazole-linked pinanamine derivatives was conducted by modifying the imidazole ring of this compound. Several compounds of this series inhibited the amantadine-sensitive virus at low micromolar concentrations. Among them, 33 was the most potent compound, which was identified as being active on an amantadine-sensitive virus through blocking of the viral M2 ion channel. Furthermore, 33 markedly inhibited the amantadine-resistant virus (IC50 = 3.4 μM) and its activity increased by almost 24-fold compared to initial compound, with its action mechanism being not M2 channel mediated.

Analgesic, antipyretic or anti-inflammatory imidazole compounds

New imidazole compounds of the formula STR1 their salts and analgesic, antipyretic and antiinflammatory pharmaceutical composition containing them. New intermediates useful in the preparation of said imidazole compounds. Process for preparing the new imid

Synthesis of 4(5)-Hydroxymethylimidazoles by Hydroxymethylation and Decarboxylation of Imidazole-4(5)-carboxylic Acids

4(5)-Hydroxymethylimidazoles were prepared by hydroxymethylation and decarboxylation of imidazole-4(5)-carboxylic acid esters.The reaction was simply carried out with aqueous formaldehyde solution in the presence of base.