80318-54-3

Upstream product

• 2585-26-4 4-nitro-N-benzylbenzamide 
• 696-60-6 4-aminomethylphenol 
• 122-04-3 4-nitro-benzoyl chloride 
• 92164-89-1 4-Nitro-benzoesaeure-<4-nitro-benzylamid> 

Downstream Products

• 1415675-05-6 4-((4-nitrobenzamido)methyl)phenyl 4-(heptyloxy)benzoate 
• 1415675-10-3 tert-butyl 2-(N-(4-hydroxybenzyl)-4-(2-(4-methoxyphenyl)acetamido)benzamido)acetate 
• 1415675-06-7 4-((N-(2-(tert-butoxy)-2-oxoethyl)-4-nitrobenzamido)methyl)phenyl 4-(heptyloxy)benzoate 
• 1415671-30-5 4-((4-amino-N-(2-(tert-butoxy)-2-oxoethyl)benzamido)methyl)phenyl 4-(heptyloxy)benzoate 
• 1415675-07-8 4-((N-(2-(tert-butoxy)-2-oxoethyl)-4-(2-(4-methoxyphenyl)acetamido)benzamido)-methyl)phenyl 4-(heptyloxy)benzoate 
• 1415669-52-1 2-(N-(4-((4-(heptyloxy)benzoyl)oxy)benzyl)-4-(2-(4-methoxyphenyl)acetamido)benzamido)-acetic acid 

Relevant academic research and scientific papers

NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS

Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1 (7-36), GLP-1 (9-36), oxyntomodulin and exendin variants.

AROMATIC HYDROXYLATION OF BENZYLAMIDES BY POTASSIUM SUPEROXIDE

N-benzylamides react with potassium superoxide in benzene in presence of 18-crown-6 ether to give ortho and para hydroxylated products.A mechanism is proposed for this reaction, involving the nucleophilic attack of superoxide anion to amide carbonyl and hydrogen abstraction from benzyle methylene by the substrate-superoxide adduct.