80323-72-4

Usage

InChI:InChI=1/C9H6N2O/c1-12-9-3-2-7(5-10)4-8(9)6-11/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 31643-49-9 4-Nitrophthalonitrile 
• 62415-74-1 3,4-dibromoanisole 
• 544-92-3 copper(I) cyanide 
• 615-56-5 3,4-dibromophenol 
• 557-21-1 zinc(II) cyanide 

Downstream Products

• 28692-27-5 5-methoxy-isoindoline-1,3-dione-1,3-diimine 

Relevant academic research and scientific papers

Mechanism-Based Development of a Low-Potential, Soluble, and Cyclable Multielectron Anolyte for Nonaqueous Redox Flow Batteries

The development of nonaqueous redox flow batteries (NRFBs) has been impeded by a lack of electroactive compounds (anolytes and catholytes) with the necessary combination of (1) redox potentials that exceed the potential limits of water, (2) high solubilit

Synthesis and photodynamic activity of zinc(II) phthalocyanine derivatives bearing methoxy and trifluoromethylbenzyloxy substituents in homogeneous and biological media

Two zinc(II) phthalocyanines bearing either four methoxy (ZnPc 3) or trifluoromethylbenzyloxy (ZnPc 4) substituents were synthesized and their photodynamic activity compared in both homogeneous medium containing photooxidizable substrate and in vitro on Hep-2 human larynx-carcinoma cell line. Although both sensitizers present similar behavior in organic solvent, a higher cell photoinactivation was found for ZnPc 3. Two zinc(II) phthalocyanines bearing either four methoxy (ZnPc 3) or trifluoromethylbenzyloxy (ZnPc 4) substituents have been synthesized by a two-step procedure starting from 4-nitrophthalonitrile. Absorption and fluorescence spectroscopic studies were analyzed in different media. These compounds are essentially non-aggregated in the organic solvent. Fluorescence quantum yields (φF) of 0.26 for ZnPc 3 and 0.25 for ZnPc 4 were calculated in tetrahydrofuran (THF). The photodynamic activity of these compounds was compared in both THF containing photooxidizable substrates and in vitro on Hep-2 human larynx-carcinoma cell line. The production of singlet molecular oxygen, O2( 1Δg), was determined using 9,10-dimethylanthracene yielding values of ～0.56 for both sensitizers. Under these conditions, the addition of β-carotene (Car) suppresses the O2( 1Δg)-mediated photooxidation. In biological medium, no dark cytotoxicity was found for cells incubated with 0.1 μM of phthalocyanines 3 and 4 for 24 h. However, under similar conditions 0.5 μM of ZnPc 4 was toxic (70% cell survival). The uptake into Hep-2 cells was evaluated using 0.1 μM of sensitizer, reaching values of ～0.05 nmol/106 cells after 3 h of incubation at 37°C. The cell survival after irradiation of the cultures with visible light was dependent upon both light exposure level and intracellular sensitizer concentration. A higher photocytotoxic effect was found for ZnPc 3 with respect to 4 (32%/70% cell survival after 15 min of irradiation). Also, these studies were performed treating the cells with 0.5 μM of ZnPc 3. In this case, an increase in the uptake (～0.28 nmol/10 6 cells) was observed, which is accompanied by a higher photocytotoxic activity (20% cell survival). These results show that even though both sensitizer present similar photophysical properties in homogeneous medium, the photodynamic behavior in cellular media can significantly be changed.

Iridium complex, preparation method thereof and photodynamic therapy drug

The invention belongs to the technical field of biological medicine, and particularly relates to an iridium complex, the structural general formula of the iridium complex is shown as a following formula I or formula II: wherein R1, R2, R3, R4, R5, R6, R7

Synthesis of phthalonitriles using a palladium catalyst

An easy synthetic method to obtain phthalonitriles from o-dibromobenzenes under mild conditions in high yields using Zn(CN)2 and a catalytic amount of tris(dibenzylideneacetone)dipalladium and 1,1′- bis(diphenylphosphino)ferrocene is described. Georg Thieme Verlag Stuttgart.

INFLUENCE OF SUBSTITUENTS ON THE BASICITY OF COPPER PHTHALOCYANINE

1.The basicities of substituted phthalocyanines depend substantially on the nature of the substituent and decrease with rise in the acceptor power of the latter, and the influence of a substituent in the 3 position is greater than that of one in the 4 pos

Metal-Chelating 1,3-bis(2'-Pyridylimino)isoindolines

A variety of novel chelating 1,3-bis(2'-pyridylimino)isoindoline ligands were prepared and characterized including ligands substituted on both the pyridyl and isoindoline ring systems.Noteworthy are the first isoindoline ligands with solubility in aqueous media.A convenient preparation of 4-alkoxyphthalonitriles is reported; these compounds are readily obtained from 4-nitrophthalonitrile and are suitable starting materials for alkoxy-substituted ligands.