80360-22-1

Upstream product

• 120-72-9 indole 
• 40899-71-6 1-benzenesulfonylindole 
• 882-33-7 diphenyldisulfane 
• 98-09-9 benzenesulfonyl chloride 
• 40900-03-6 1-(benzenesulfonyl)-2-lithioindole 

Downstream Products

• 1242733-96-5 3-t-butyl-2-(phenylsulfonyl)-1H-indole 
• 16823-62-4 butyl phenyl sulfone 
• 34009-06-8 (±)-(sec-butylsulfonyl)benzene 
• 83-34-1 3-Methylindole 
• 108665-95-8 3-methyl-2-(phenylsulfonyl)-1H-indole 
• 58550-84-8 N-(phenylsulphonyl)-3-methylindole 
• 193686-88-3 1,2-bis(phenylsulfonyl)-1H-indole 

Relevant academic research and scientific papers

1,2-Bis(phenylsulfonyl)-1H-indole as an acceptor of organocuprate nucleophiles

1,2-Bis(phenylsulfonyl)-1H-indole is a novel example of an electron-deficient indole that undergoes nucleophilic attack at C-3. Though a variety of other organometallic nucleophiles fail to engender nucleophilic substitution, organocuprates produce 3-substituted 2-(phenylsulfonyl)-1H- indoles. These reactions contribute to the growing number of examples of nucleophilic addition to the indole core. ARKAT USA, Inc.

Generation and Reactions of 3-Lithio-1-(phenylsulfonyl)indole

Treatment of 1-(phenylsulfonyl)-3-iodoindole (6) with 2 equiv of tert-butyllithium (-100 deg C THF) generates essentially quantitatively 3-lithio-1-(phenylsulfonyl)indole (1).Quenching 1 with various electrophiles gives 3-substituted indoles in good yield