804499-51-2Relevant articles and documents
Dimethyl-diphenyl-propanamide derivatives as nonsteroidal dissociated glucocorticoid receptor agonists
Yang, Bingwei V.,Weinstein, David S.,Doweyko, Lidia M.,Gong, Hua,Vaccaro, Wayne,Huynh, Tram,Xiao, Hai-Yun,Doweyko, Arthur M.,McKay, Lorraine,Holloway, Deborah A.,Somerville, John E.,Habte, Sium,Cunningham, Mark,McMahon, Michele,Townsend, Robert,Shuster, David,Dodd, John H.,Nadler, Steven G.,Barrish, Joel C.
experimental part, p. 8241 - 8251 (2011/02/21)
A series of 2,2-dimethyl-3,3-diphenyl-propanamides as novel glucocorticoid receptor modulators is reported. SAR exploration led to the identification of 4-hydroxyphenyl propanamide derivatives displaying good agonist activity in GR-mediated transrepressio
