30090-97-2

Upstream product

• 578-58-5 2-methylmethoxybenzene 
• 2078-12-8 trimethylsilyl benzoate 
• 31040-84-3 4-tert-butyl-2-methylanisole 
• 98-88-4 benzoyl chloride 
• 93-97-0 benzoic acid anhydride 
• 6304-99-0 dimethyl 2,3-bis(benzoyloxy)succinate 
• 65582-59-4 dimethyl 2-(benzoyloxy)succinate 
• 17637-11-5 2,3-bis-benzoyloxy-succinic acid anhydride 
• 611-94-9 4-Methoxybenzophenone 
• 5158-46-3 methylzinc chloride 
• 14804-31-0 2-methyl-4-bromoanisole 
• 74-88-4 methyl iodide 
• 65-85-0 benzoic acid 

Downstream Products

• 861096-18-6 Hydroxy-diphenyl-(4-methoxy-3-methyl-phenyl)-methan 
• 412018-25-8 (+/-)-Hydroxy-phenyl-(4-methoxy-3-methyl-phenyl)-(naphthyl-⁽¹⁾)-methan 
• 804499-51-2 (4-methoxy-3-methyl-phenyl)-phenyl-methanol 
• 108552-35-8 3-Bromomethyl-4-methoxybenzophenone 
• 5326-42-1 3-methyl-4-hydroxybenzophenone 
• 103158-41-4 2-methyl-4-trityl-anisole 
• 854749-99-8 4-(α-bromo-benzhydryl)-2-methyl-anisole 
• 409320-38-3 4-(chloro-[1]naphthyl-phenyl-methyl)-2-methyl-anisole 
• 409320-33-8 2-methyl-4-([1]naphthyl-phenyl-methylene)-cyclohexa-2,5-dienone 

Relevant academic research and scientific papers

Synthesis and catalytic reactivity in Friedel–Crafts acylations of monobridged bis(cyclopentadienyl)molybdenum(I) carbonyl complexes

When the monobridged biscyclopentadienes (C5H5)R(C5H5) [R = C(CH3)2 (1), Si(CH3)2 (2), C(CH2)5 (3)] reacted with Mo(CO)6 in refluxing xylene, the corresponding complexes [(η5-C5H4)2R][Mo(CO)3]2 [R = C(CH3)2 (4), Si(CH3)2 (5), C(CH2)5 (6)] were obtained. These complexes were separated by chromatography and characterized by elemental analysis, IR, and 1H NMR spectroscopy. The molecular structures of 4 and 5 were determined by X-ray diffraction analysis. Friedel–Crafts acylation reactions of anisole derivatives with aromatic or aliphatic acyl chlorides catalyzed by complexes 4–6 showed that all of these monobridged bis(cyclopentadienyl)molybdenum carbonyl complexes have catalytic activity.

Syntheses, structures, and catalytic activity in Friedel–Crafts acylations of substituted tetramethylcyclopentadienyl molybdenum carbonyl complexes

Reactions of the substituted tetramethylcyclopentadienes [C5HMe4R] [R?=?tBu, Ph, CH2CH2C(CH3)3] with Mo(CO)3(CH3CN)3 in refluxing xylene gave a series of dinuclear molybdenum carbonyl complexes [(η5-C5Me4R)Mo(CO)3]2 [R?=?tBu (1), Ph (2), CH2CH2C(CH3)3 (3)], [(η5-C5MetBu)Mo(μ-CO)2]2 (4)], and [(η5-C5Me4)tBu]2Mo2O4(μ-O) (5)], respectively. Complexes 1–5 were characterized by elemental analysis, IR, 1H NMR, and 13C NMR spectroscopy. In addition, their crystal structures were determined by X-ray crystal diffraction analysis. The catalytic activities of complexes 1–3 in Friedel–Crafts acylation in the presence of o-chloranil has also been investigated; the reactions were achieved under mild conditions to give the corresponding products in moderate yields.

Selective Methylation of Arenes: A Radical C?H Functionalization/Cross-Coupling Sequence

A selective, nonchelation-assisted methylation of arenes has been developed. The overall transformation, which combines a C?H functionalization reaction with a nickel-catalyzed cross-coupling, offers rapid access to methylated arenes with high para selectivity. The reaction is amenable to late-stage methylation of small-molecule pharmaceuticals.

Two-step one-pot synthesis method for meta-substituted diphenyl ketone compound

The invention discloses a two-step one-pot synthesis method for a meta-substituted diphenyl ketone compound. According to the method, transition metal palladium is used as a catalyst, anhydrous sodium acetate is used as an additive, aromatic acid and a benzoylformic compound are subjected to an ortho-position C-H functionalization reaction based on carboxyl groups, then by means of the synergistic effect of CuO and the additive anhydrous sodium acetate, a decarboxylation coupling reaction is directly carried out without separating products, and the meta-substituted diphenyl ketone compound is synthesized through the two-step one-pot method. The two-step one-pot synthesis method has the advantages that the raw materials are simple and easy to obtain, reaction operations are simple, the method is environmentally friendly, and the product yield is high.

Friedel-crafts acylation reactions using esters

Intermolecular and intramolecular Friedel-Crafts acylation reactions of various aliphatic and aromatic esters at room temperature with the use of very simple reagents and activating groups in are described. The products were obtained in good yield (60-85 %). The detailed mechanistic pathway was studied by DFT calculations and supported by experimental evidence. Copyright

Unexpectedly high activity of Zn(OTf)2·6H2O in catalytic Friedel-Crafts acylation reaction

Zn(OTf)2·6H2O was used to promote Friedel-Crafts acylation of aromatics. The work describes the high activity and efficiency of Zn(OTf)2·6H2O in acylation of aromatics, and the catalyst has surpassed most metal triflates in dispensing when dried at high temperature under vacuum before use. Copyright Taylor & Francis Group, LLC.

Aluminum dodecatungstophosphate (AlPW12O40) as a non-hygroscopic Lewis acid catalyst for the efficient Friedel-Crafts acylation of aromatic compounds under solvent-less conditions

Stable and non-hygroscopic aluminum dodecatungstophosphate (AlPW 12O40), which is prepared easily from cheap and commercially available compounds was found to be an effective catalyst for Friedel-Crafts acylation reactions using carboxylic acids, acetic anhydride and benzoyl chloride in the absence of solvent under mild reaction conditions.

Solvent-free Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of trifluoroacetic anhydride and aluminum dodecatungstophosphate

The stable and non-hygroscopic aluminum dodecatungstophosphate (AlPW12O40), was found to be an effective catalyst (3 mol%) for the solvent-free Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of trifluoroacetic anhydride under mild reaction conditions.

Preparation of ethyl 6-methoxy-7-methyl-1-aryl/cyclohexyl-4-oxo-2-naphthoates as an intermediates for synthesis of β-apopicropodophyllin analogues

Preparation of tetralone ester 4a-c, an intermediate for the synthesis of β-apopicropodophyllin analogues via Stobbe condensation of benzophenone derivatives followed by Friedel Craft's cyclization is described.

The catalytic Friedel-Crafts acylation reaction of aromatic compounds with carboxylic anhydrides using combined catalyst system of titanium(IV) chloride tris(trifluoromethanesulfonate) and trifluoromethanesulfonic acid

Various aromatic ketones are prepared in good to high yields with carboxylic anhydrides using combined catalyst system of TiCl(OTf)3 and TfOH.