80517-22-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-4-fluorobenzonitrile is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for the creation of molecules with specific biological activities, making it valuable in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Amino-4-fluorobenzonitrile serves as a precursor in the production of pesticides and other crop protection agents. Its incorporation into these compounds can enhance their effectiveness in protecting crops from pests and diseases.
Used in Organic Synthesis:
2-Amino-4-fluorobenzonitrile is utilized as a building block in organic synthesis, particularly for the development of heterocyclic compounds. Its presence in these compounds can impart novel properties and reactivity, broadening the scope of organic chemistry.
Used in Dye and Pigment Production:
As an intermediate in the production of dyes and pigments, 2-Amino-4-fluorobenzonitrile contributes to the creation of a wide range of colorants used in various industries, including textiles, plastics, and printing inks. Its role in these applications is crucial for achieving specific color characteristics and performance properties.

InChI:InChI=1/C7H5FN2/c8-6-2-1-5(4-9)7(10)3-6/h1-3H,10H2

Upstream product

• 3939-09-1 2,4-difluorobenzonitrile 
• 394-01-4 4-fluoro-2-nitrobenzoic acid 
• 75-64-9 tert-butylamine 
• 364-78-3 2-nitro-4-fluoroaniline 
• 446-32-2 4-fluoroanthranilic acid 
• 119023-25-5 4-fluoroanthranilamide 
• 80517-21-1 4-fluoro-2-nitrobenzonitrile 

Downstream Products

• 80517-28-8 (2-Amino-4-fluoro-phenyl)-thiophen-2-yl-methanone 
• 80517-29-9 (2-Amino-4-fluoro-phenyl)-(5-methyl-thiophen-2-yl)-methanone 
• 80517-31-3 (2-Amino-4-fluoro-phenyl)-(5-chloro-thiophen-2-yl)-methanone 
• 104586-56-3 N-(3-oxo-cyclohexen-1-yl)-2-amino-4-fluorobenzonitrile 
• 165107-97-1 N-(2-cyano-5-fluorophenyl)acetamide 
• 174566-15-5 2,4,-dichloro-7-fluoroquinazoline 
• 76088-98-7 7-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline 
• 50817-53-3 (2-amino-4-fluorophenyl)(phenyl)methanone 

Relevant academic research and scientific papers

Benzene, Pyridine, and Pyridazine Derivatives

Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R3, and R4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/o

Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: Molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives

Continuing our work on tetracyclic tacrine analogues, we synthesized a series of acetylcholinesterase (AChE) inhibitors of 11H-indeno-[1,2-b]-quinolin-10-ylaminic structure. Selected substituents were placed in synthetically accessible positions of the tetracyclic nucleus, in order to explore the structure-activity relationships (SAR) and the mode of action of this class of anticholinesterases. A molecular modeling investigation of the binding interaction of the lead compound (1a) with the AChE active site was performed, from which it resulted that, despite the rather wide and rigid structure of 1a, there may still be the possibility to introduce some small substituent in some positions of the tetracycle. However, from the examination of the experimental IC50 values, it derived that the indenoquinoline nucleus probably represents the maximum allowable molecular size for rigid compounds binding to AChE. In fact, only a fluorine atom in position 2 maintains the AChE inhibitory potency of the parent compound, and, actually, increases the AChE-selectivity with respect to the butyrylcholinesterase inhibition. By studying the kinetics of AChE inhibition for two representative compounds of the series, it resulted that the lead compound (1a) shows an inhibition of mixed type, binding to both the active and the peripheral sites, while the more sterically hindered analogue 2nScheme 1Reagents: (a) ZnCl2 reflux; (b) (1) benzaldehyde reflux, (2) NaBH4. seems to interact only at the external binding site of the enzyme. This finding seems particularly important in the context of Alzheimer's disease research in the light of recent observations showing that peripheral AChE inhibitors might decrease the aggregating effects of the enzyme on the β-amyloid peptide (βA). Copyright (C) 2000 Elsevier Science Ltd.

3-AMIDOINDOLYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF

The present invention is directed to a new class of 3-amido and 3-sulfamido-indolyl NMDA antagonists and their use in the treatment of a number of disease states.