80581-75-5

Upstream product

• 80541-14-6 3-O-acetyl-5-O-benzoyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 
• 24467-33-2 (3aR,5R,6R,6aR)-5-(hydroxymethyl)-2,2,6-trimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol 
• 51533-02-9 3-C-Methyl-1,2-O-isopropylidene-α-D-allofuranose 
• 6698-46-0 5-O-benzoyl-1,2-O-isopropylidene-α-D-ribofuranos-3-ulose 
• 6022-96-4 5-O-benzoyl-α-D-xylofuranose 
• 16831-81-5 ((3aR,5R,6R,6aR)-6-hydroxy-2,2,6-trimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate 
• 6612-91-5 ((3aR,5R,65,6aR)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate 
• 108-24-7 acetic anhydride 
• 89157-83-5 ((2R,3S,4R,5S)-3,4,5-trihydroxy-3-methyltetrahydrofuran-2-yl)methyl benzoate 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 98-88-4 benzoyl chloride 
• 35784-67-9 1,2;5,6-di-O-isopropylidene-3-C-methyl-α-D-allofuranose 
• 89157-83-5 5-O-benzoyl-3-C-methyl-α,β-D-ribofuranose 

Downstream Products

• 141232-11-3 4-chloro-5-cyano-7-(2',3'-di-O-acetyl-5'-O-benzoyl-3'-C-methyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidine 
• 89195-77-7 1,2,3-tri-O-acetyl-5-O-benzoyl-3-C-methyl-α-D-ribofuranose 
• 80541-16-8 1-(2,3-di-O-acetyl-5-O-benzoyl-3-C-methyl-β-D-ribofuranosyl)cytosine 
• 849241-87-8 6-chloro-9H-(2,3-di-O-acetyl-5-O-benzoyl-3-C-methyl-β-D-ribofuranosyl)purine 
• 917241-28-2 C₂₈H₂₈N₄O₁₁ 
• 934002-38-7 6-chloro-9-(2,3-di-O-acetyl-5-O-benzoyl-3-C-methyl-β-D-ribofuranosyl)-9H-purin-2-amine 
• 80541-17-9 1-(2,3-di-O-acetyl-5-O-benzoyl-3-C-methyl-β-D-ribofuranosyl)uracil 

Relevant academic research and scientific papers

CD73 INHIBITORS

Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

CD73 INHIBITORS

Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

EPIMERIZATION DURING THE ACETOLYSIS OF 3-O-ACETYL-5-O-BENZOYL-1,2-O-ISOPROPYLIDENE-3-C-METHYL-α-D-RIBOFURANOSE. SYNTHESIS OF 3'-C-METHYLNUCLEOSIDES WITH THE β-D-ribo- AND α-D-arabino CONFIGURATIONS

Acetolysis of 3-O-acetyl-5-O-benzoyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose with a high concentration of acetic acid yielded 1,2,3-tri-O-acetyl-5-O-benzoyl-3-C-methyl-D-arabinofuranose, which was used for the preparation of 3-C-methyl-α-D-arabinofuranosyl nucleosides. 3'-C-Methylribonucleosides were also synthesized starting from 1,2,3-tri-O-acetyl-5-O-benzoyl-3-C-C-methyl-D-ribofuranose.

SYNTHESIS AND PROPERTIES OF 3'-C-METHYLNUCLEOSIDES AND THEIR PHOSPHORIC ESTERS

3'-C-Methyluridine and 3'-C-methylcytidine were synthesized in 11 steps starting from D-glucose.The conformation of 3'-C-methylnucleosides was studied in solution and in the cystal by using the techniques of c.d., 1H-n.m.r spectroscopy, and X-ray diffract