80625-19-0

Upstream product

• 32803-73-9 methyl 3-phenyl-3-chloro-2-ketopropionate 
• 100-52-7 benzaldehyde 
• 80625-18-9 methyl 2-amino-5-phenyl-1,3-thiazole-4-carboxylate 

Downstream Products

• 1047675-14-8 2-chloro-5-phenyl-1,3-thiazole-4-carboxylic acid 
• 127918-95-0 t-butyl [2-(2-chloro-5-phenyl-4-thiazolecarboxamido)ethyl]carbamate 

Relevant academic research and scientific papers

SUBSTITUTED 2-AZABICYCLO[3.1.1]HEPTANE AND 2-AZABICYCLO[3.2.1]OCTANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

There is provided a compound of formula (I), wherein L1 to L3, R1 to R4, X, A and B have meanings given in the description, and pharmaceutically acceptable salts, solvates and prodrugs thereof, which compounds are useful as antagonists of the orexin-1 and orexin-2 receptors or as selective antagonists of the orexin-1 receptor, and thus, in particular, in the treatment or prevention of inter alia substance dependence, addiction, anxiety disorders, panic disorders, binge eating, compulsive disorders, impulse control disorders, cognitive impairment and Alzheimer's disease.

2-Substituted-5-phenyl-4-thiazolecarboxylic acids and their derivatives as safening agents

2-Substituted-5-phenyl-4-thiazolecarboxylic acids and their derivatives have been found to be effective in reducing herbicidal injury to sorghum plants caused by triallate, alachlor and butachlor herbicides, and especially in reducing herbicidal injury to sorghum plants caused by alachlor herbicide.