807318-79-2

Upstream product

• 36848-69-8 ethyl 2-cyano-2-(3,4-dimethoxyphenyl)acetate 
• 1798-09-0 m-methoxyphenylacetic acid 
• 56003-06-6 ethyl 3-amino-2-(3,4-dimethoxyphenyl)propanoate 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 

Downstream Products

• 798566-18-4 6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carboxylic acid methoxy-amide trifluoroacetate salt 
• 798566-32-2 {[6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carbonyl]-amino}-acetic acid ethyl ester acetic acid salt 
• 798566-16-2 6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carboxylic acid hydroxyamide trifluoroacetate salt 
• 798566-20-8 6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carboxylic acid methoxy-methyl-amide trifluoroacetate salt 
• 798566-12-8 6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carboxylic acid (2-morpholin-4-yl-ethyl)-amide 
• 798566-31-1 {[6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carbonyl]-amino}-acetic acid ethyl ester 
• 798566-14-0 6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carboxylic acid (2-cyano-ethyl)-amide 
• 798566-19-5 6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carboxylic acid methoxy-methyl-amide 
• 798566-17-3 6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carboxylic acid methoxy-amide 
• 798566-15-1 6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carboxylic acid hydroxyamide 
• 798563-13-0 1-(3-methoxybenzyl)-4-cyanomethyl-6,7-dimethoxyisoquinoline 
• 798563-12-9 1-(3-methoxybenzyl)-4-chloromethyl-6,7-dimethoxyisoquinoline 
• 798563-11-8 1-(3-methoxybenzyl)-4-hydroxymethyl-6,7-dimethoxyisoquinoline 

Relevant academic research and scientific papers

Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors

Through high throughput screening and subsequent hit identification and optimization, we synthesized a series of 1-arylcarbonyl-6,7- dimethoxyisoquinoline derivatives as the first reported potent and reversible GFAT inhibitors. SAR studies of this class o

GFAT INHIBITORS

Compounds of formula (I) are provided as well as pharmaceutically acceptable salts and esters thereof, wherein the substituents are as disclosed in the specification. The compounds have utility for the treatment of type 2 diabetes mellitus.