139036-69-4

Basic information

• Product Name: Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester
• CAS NO: 139036-69-4
• Molecular Weight: 1209.76
• Mol File: 139036-69-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester(139036-69-4)
• EPA Substance Registry System: Phosphoric acid benzotriazol-1-yl ester (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(tert-butyl-diphenyl-silanyloxymethyl)-benzoylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester(139036-69-4)

Safety Data

• Hazardous Substances Data: 139036-69-4(Hazardous Substances Data)

Upstream product

• 951-77-9 2'-Deoxycytidine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 51432-42-9 4-Amino-1-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one 
• 398148-63-5 2-(tert-Butyl-diphenyl-silanyloxymethyl)-N-[2-oxo-1-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-1,2-dihydro-pyrimidin-4-yl]-benzamide 
• 139036-59-2 4-N-[2-(tert-butyldiphenylsilyloxymethyl)]benzoyl deoxycytidine 
• 129452-86-4 2-<(tert-butyldiphenylsilyloxy)methyl>benzoyl chloride 
• 132286-88-5 2-(((tert-butyldiphenylsilyl)oxy)methyl)benzoic acid 
• 132286-87-4 (2-Bromo-benzyloxy)-tert-butyl-diphenyl-silane 
• 18982-54-2 o-bromobenzyl alcohol 
• 80817-46-5 bis(benzotriazol-1-yl)(2-chlorophenyl)phosphate 
• 129452-87-5 N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-benzamide 

Relevant articles and documents

A new protected acyl protecting group for exocyclic amino functions of nucleobases

2-(Tert-butyldiphenylsilyloxymethyl)benzoyl chloride (SiOMB-Cl) reacts with the per-O-trimethylsilylated d-nucleosides C,G and A to give, after removal of the Si(Me)3 groups and 5′-O-protection with 4,4′-dimethoxytrityl chloride (DMT-Cl), the corresponding N-SiOMB-5′-O-DMT derivates, the SiOMB groups of which can easily be removed by fluoride ion. The SiOMB protected nucleosides proved to be suitable building units for the preparation of DNA fragments in solution and on a solid support.