80845-58-5

Basic information

• Product Name: Methyl 1-Benzyl-1,2,3,6-tetrahydropyridine-4-carboxylate
• Synonyms: Methyl 1-Benzyl-1,2,3,6-tetrahydropyridine-4-carboxylate;4-Pyridinecarboxylicacid,1,2,3,6-tetrahydro-1-(phenylMethyl)-,Methylester;1,2,3,6-Tetrahydro-1-(phenylmethyl)-4-pyridinecarboxylic acid methyl ester
• CAS NO: 80845-58-5
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231
• Mol File: 80845-58-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 328.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.129±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.08±0.40(Predicted)
• CAS DataBase Reference: Methyl 1-Benzyl-1,2,3,6-tetrahydropyridine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1-Benzyl-1,2,3,6-tetrahydropyridine-4-carboxylate(80845-58-5)
• EPA Substance Registry System: Methyl 1-Benzyl-1,2,3,6-tetrahydropyridine-4-carboxylate(80845-58-5)

Safety Data

• Hazardous Substances Data: 80845-58-5(Hazardous Substances Data)

Usage

General Description

Methyl 1-benzyl-1,2,3,6-tetrahydropyridine-4-carboxylate is a chemical compound that is commonly used in pharmaceuticals and research. It is a synthetic derivative of tetrahydropyridine and carboxylic acid, and its molecular structure consists of a benzene ring linked to a tetrahydropyridine ring with a methyl ester group attached to the carboxylic acid. This chemical has been studied for its potential therapeutic properties, particularly in the treatment of neurological disorders such as Parkinson's disease. Additionally, it has also been investigated for its role as a precursor or intermediate in the synthesis of other organic compounds. Overall, methyl 1-benzyl-1,2,3,6-tetrahydropyridine-4-carboxylate is a versatile compound with potential applications in both medicinal and chemical fields.

Upstream product

• 94983-57-0 1-benzyl-4-(methoxycarbonyl)pyridin-1-ium 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 100-39-0 benzyl bromide 
• 10315-06-7 1-benzylpiperidine-4-carboxylic acid methyl ester 
• 100-44-7 benzyl chloride 
• 143-33-9 sodium cyanide 
• 1216-01-9 1-Benzyl-4-methoxycarbonyl-pyridinium; iodide 

Downstream Products

• 95533-24-7 1-(1-benzyl-3-ethyl-4-piperidyl)-1-propanone 
• 792136-23-3 methyl 1,2,3,6-tetrahydro-4-pyridinecarboxylate 
• 184368-74-9 3,6-dihydro-2H-pyridine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester 
• 926044-48-6 methyl 1-benzyl-3-(3-bromo5-methyl-phenyl)piperidine-4-carboxylate 
• 926044-38-4 methyl 1-benzyl-3-(3-bromophenyl)piperidine-4-carboxylate 

Relevant articles and documents

Novel Compounds as Autotaxin Inhibitors and Pharmaceutical Compositions Comprising the Same

The present invention relates to a novel autotaxin inhibitor compound for preventing and treating disease or symptoms due to an increase in concentration of lysophosphatidic acid or activation of autotaxin. The present invention further relates to a pharmaceutical composition containing the same. The novel compound of the present invention is an autotaxin inhibitor which inhibits production of lysophosphatidic acid, and thus is useful for treating or preventing cardiovascular disease, cancer, metabolic disease, kidney disease, liver disease, inflammatory diseases, nervous disease, respiratory disease, desmoid disease, eye disease, cholestatic symptoms, other types of chronic pruritus or acute, or chronic rejection of transplanted organs.COPYRIGHT KIPO 2017

Synthetic Applications of 2-Cyano-1,2,3,6-tetrahydropyridines. 2. Synthesis of Isodasycarpidone and Related Systems, the Ervitsine Skeleton, and Its Benzo Analogue

The synthesis of isodasycarpidone (8a), N-demethylisodasycarpidone (9a), and their epi derivatives 8b and 9b is described.The condensation of an appropriate 2-cyano-1,2,3,6-tetrahydropyridine with indole and the conjugate addition of diethylcopper(I)-magnesium bromide to the resulting α,β-unsaturated esters constitute the key steps of this synthesis.A similar condensation from methyl 2-cyano-1-methyl-1,2,3,6-tetrahydropyridine-4-acetate (11) and indolylmagnesium iodide or (m-methoxyphenyl)magnesium bromide, followed by catalytic hydrogenation, hydrolysis, and PPA cyclization establishes synthetic routes to the tetracyclic framework (16) of the indole alkaloid ervitsine and its benzo analogue 19.