80870-40-2

Basic information

• Product Name: H-Phe-Ala-OtBu
• Synonyms: H-Phe-Ala-OtBu
• CAS NO: 80870-40-2
• Molecular Weight: 292.378
• Mol File: 80870-40-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: H-Phe-Ala-OtBu(CAS DataBase Reference)
• NIST Chemistry Reference: H-Phe-Ala-OtBu(80870-40-2)
• EPA Substance Registry System: H-Phe-Ala-OtBu(80870-40-2)

Safety Data

• Hazardous Substances Data: 80870-40-2(Hazardous Substances Data)

Upstream product

• 21691-50-9 Ala-OtBu 
• 63-91-2 L-phenylalanine 
• 16503-49-4 (E)-methyl 2-(hydroxyimino)-3-phenylpropanoate 
• 13404-22-3 tert-butyl L-alaninate hydrochloride 
• 738-75-0 (S)-3-phenyl-2-phenylacetylamino-propionic acid 
• 312933-66-7 N-(2,3,4,6-Tetra-O-acetyl-β-D-galactopyranosyloxycarbonyl)-L-phenylalanyl-L-alanine tert-butyl ester 
• 1161-13-3 N-Cbz-L-Phe 
• 33033-71-5 (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoate 
• 312933-73-6 N-(β-D-Galactopyranosyloxycarbonyl)-L-phenylalanyl-L-alanine tert-butyl ester 
• 116912-20-0 N-(Phenylacetyl)-L-phenylalanyl-L-alanin-tert-butylester 

Downstream Products

• 1106947-20-9 Fmoc-Ser(tBu)-Phe-Ala-OtBu 
• 481054-29-9 N-acetylglycyl-L-leucyl-3-chloro-L-alanyl-L-phenylalanyl-L-alanine tert-butyl ester 
• 481054-30-2 N-acetylglycyl-L-leucyl-3-chloro-L-alanyl-L-phenylalanyl-L-alanine 
• 481054-28-8 N-(benzyloxycarbonyl)-3-chloro-L-alanyl-L-phenylalanyl-L-alanine tert-butyl ester 

Relevant articles and documents

Catalytic Peptide Synthesis: Amidation of N-Hydroxyimino Esters

A catalytic method for the formation of amide bonds was developed in which the amidation of N-hydroxyimino esters with a broad range of amino acid tert-butyl esters is promoted by a niobium catalyst in the absence of solvent. Contrary to the predominant protocol based on reagent control commonly applied to amidation reactions, this study provides insight into an approach based on substrate control. This system affords the corresponding amides in high yields in addition to being both highly atom efficient and racemization-free. An advantage of this system is shown in that the Lewis acid catalysis proceeds chemoselectively in the presence of nonactivated esters. Furthermore, the resulting amides are easily transformed into their corresponding di- and tripeptides with high diastereoselectivities under simple hydrogenation conditions.

Synthesis of Silacyclic Dipeptides: Peptide Elongation at Both N-And C-Termini of Dipeptide

A new type of peptide bond formation utilizing silacyclic amino acids or peptides is described. This work has the following advantages: (1) imidazolylsilane is a highly fascinating coupling reagent for dipeptide synthesis from N-,C-Terminal unprotected am

METHOD FOR PRODUCING AMIDE COMPOUND

Provided is a novel method for producing amide compounds at high stereochemical selectivities. The method according to the present invention for producing amide compounds is provided with an amidation step for reacting, in the presence of a catalyst compr