808769-11-1

Upstream product

• 67-56-1 methanol 
• 1346424-45-0 3-(2-Hydroxy-2-methylpropyl)benzoic acid 
• 205927-63-5 3-(2-oxopropyl)benzoic acid 
• 3762-39-8 1-(3-bromophenyl)-2-methylpropan-2-ol 
• 21906-32-1 3-bromophenylacetone 
• 808769-13-3 [2-(3-bromophenyl)-1,1-dimethylethyl]carbamic acid tert-butyl ester 
• 808769-15-5 N-[2-(3-bromophenyl)-1,1-dimethylethyl]-2-chloroacetamide 
• 808769-14-4 1-(3-bromophenyl)-2-methylpropan-2-amine 
• 808769-12-2 3-(2-tert-butoxycarbonylamino-2-methylpropyl)benzoic acid methyl ester 

Downstream Products

• 1346424-75-6 (R)-3-{2-[2-[4-benzyloxy-3-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-(tert-butyldimethylsilanyloxy)ethylamino]-2-methylpropyl}benzoic acid 
• 1346424-72-3 (R)-methyl 3-[2-[[2-[4-(benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]phenyl]-2-[(tert-butyldimethylsilyl)oxy]ethyl]amino]-2-methylpropyl]benzoate 
• 1346424-77-8 (R)-3-(2-((2-(8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl)-2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-2-methylpropyl)benzoic acid 
• 865874-73-3 (R)-methyl 3-(2-((2-(8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl)-2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-2-methylpropyl)benzoate 
• 865799-48-0 3-{2-[(R)-2-(3,5-bis-benzyloxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethylamino]-2-methyl-propyl}-benzoic acid methyl ester 
• 864154-15-4 3-{2-[(2R)-2-(4-benzyloxy-3-hydroxymethylphenyl)-2-(tert-butyldimethyl-silanyloxy)ethylamino]-2-methylpropyl}benzoic acid methyl ester 

Relevant academic research and scientific papers

BI-FUNCTIONAL PYRAZOLOPYRIDINE COMPOUNDS

This invention provides compounds of the formula: wherein X is wherein R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring and all other variables are as defined herein, their use in pulmonary inflammation or bronchoconstriction therapy and compositions comprising and processes for preparing the same are provided.

Use of 5-hydroxy-4H-benzo[1,4]oxazin-3-ones as β2-adrenoceptor agonists

Novel β2-agonists with a 5-hydroxy-4H-benzo[1,4]oxazin-3-one moiety as head group are described. Systematic chemical variations at the phenethylamine residue of these compounds lead to the discovery of compound 6m as potent, full agonist of the β2-adrenoceptor with a high β1/β2-selectivity. Molecular modeling revealed an interaction between the carboxylic acid group of 6m and a lysine residue (K305) of the β2-receptor as putative explanation for the high observed selectivity. Further, compound 6m displayed in a guinea pig in vivo model a complete reversal of acetylcholine induced bronchoconstriction which lasted over the complete study time of 5 h.

COMPOUNDS FOR THE TREATMENT OF DISEASES

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in

Phenylethanolamine derivatives as beta-2 agonists

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in

Compounds for the treatment of diseases

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in