809-51-8Relevant articles and documents
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Prelog et al.
, p. 1080,1086 (1947)
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Synthesis of new 7-aminosterol squalamine analogues with high antimicrobial activities through a stereoselective titanium reductive amination reaction
Loncle, Celine,Salmi, Chanaz,Letourneux, Yves,Brunel, Jean Michel
, p. 12968 - 12974 (2007)
A series of 7-amino- and polyaminosterol analogues of squalamine and trodusquemine were synthesized involving a new stereoselective titanium reductive amination reaction in high chemical yields of up to 95% in numerous cases. These derivatives were evaluated for their in vitro antimicrobial properties against human pathogens. All the compounds present excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and Streptococcus faecalis with minimum inhibitory concentrations (MICs) varying from 2.5 to 10 μg/mL. Numerous derivatives possess also MICs against Gram-negative Escherichia coli bacteria (MICs varying from 2.5 to 10 μg/mL) suggesting that nature of the amino group attached to the sterol moiety plays an important role on the activities of such products.
Synthesis of 7α- and 7β-spermidinylcholesterol, squalamine analogues
Choucair,Dherbomez,Roussakis,El Kihel
, p. 4213 - 4216 (2004)
Stereoselective synthesis of squalamine dessulfates analogues, 7α and 7β-N-[3N-(4-aminobutyl) aminopropyl]aminocholesterol are reported, using 7α and 7β-aminocholesterol as a key intermediate. It's the first example in which the position of spermidine is modified at the steroid ring. These molecules showed a comparable antibacteria and fungi activities to squalamine. Then, they have a cytotoxic activity on a human non-small cell bronchopulmonary carcinoma line (NSCLC-N6).
Novel industrial method for preparing vitamin D3 by taking stigmasterol as raw material
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Paragraph 0010; 0046; 0047, (2021/05/05)
The invention provides a novel industrial method for preparing vitamin D3 by taking stigmasterol as a raw material. The method comprises the following steps: sequentially carrying out hydroxyl acetylation, side chain oxidation, side chain isopentane reduction and hydrogenation on stigmasterol to obtain cholesterol acetate, and then sequentially carrying out oxidation, hydrazone formation, hydrazone removal, hydrolysis, illumination and the like to obtain the vitamin D3. The invention provides a novel method for preparing vitamin D3 from stigmasterol, and the method has the advantages of mild reaction conditions and high yield, and is suitable for industrial production.
Preparation method and application of 7-ketocholesterol acetate
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Paragraph 0043-0070, (2020/11/26)
The invention relates to a preparation method of 7-ketocholesterol acetate. The preparation method comprises the following steps: (1) dissolving cholesterol acetate, a catalyst, an initiator and an antioxidant in a mixed solvent to obtain a first mixed solution, and introducing oxygen into the first mixed solution to perform oxidation reaction on cholesterol acetate and oxygen to obtain a second mixed solution; and (2) treating the second mixed solution to obtain the 7-ketocholesterol acetate. The invention also relates to an application of the 7-ketocholesterol acetate obtained by the preparation method in preparation of 7-dehydrocholesterol. According to the preparation method, the antioxidant is added so that free radicals of reactants in a reaction system can be effectively prevented from being subjected to polymerization reaction, the reaction selectivity can be improved, and the yield and the purity of the target product 7-ketocholesterol acetate can be improved.
