80924-06-7Relevant academic research and scientific papers
First total synthesis of theopederin B
Nishii, Yoshinori,Higa, Tsuyoshi,Takahashi, Shunya,Nakata, Tadashi
, p. 3597 - 3601 (2009)
Total synthesis of theopederin B, isolated from marine sponge, was accomplished by coupling pederic acid, as the left half, with trioxodecaline amine as the right half. Key reactions for synthesizing the amine were SmI2-promoted Reformatsky rea
Total synthesis of an immunosuppressive glycolipid, (2S,3S,4R)-1-O- (α-D-galactosyl)-2-tetracosanoylamino-1,3,4-nonanetriol
Murata, Kenji,Toba, Tetsuya,Nakanishi, Kyoko,Takahashi, Bitoku,Yamamura, Takashi,Miyake, Sachiko,Annoura, Hirokazu
, p. 2398 - 2401 (2007/10/03)
(Chemical Equation Presented) A practical and efficient total synthesis of (2S,3S,4R)-1-O-(α-D-galactosyl)-2-tetracosanoylamino-1,3,4-nonanetriol, OCH 1b, a potential therapeutic candidate for Th1-mediated autoimmune diseases, is described. The synthesis
Synthesis of Enantiopure 2-C-Methyl-D-erythritol 4-Phosphate and 2,4-Cyclodiphosphate from D-Arabitol
Urbansky, Marek,Davis, Chad E.,Surjan, Jacob D.,Coates, Robert M.
, p. 135 - 138 (2007/10/03)
(Equation presented) Two key intermediates of the newly discovered mevalonate-independent pathway for isoprenoid biosynthesis were prepared. Optically pure 2-C-methyl-D-erythritol 4-phosphate and 2,4-cyclodiphosphate were chemically synthesized from D-arabitol using a convenient benzylidene and tert-butyldimethylsilyl protection of polyhydroxylated intermediates. The new scheme offers a straightforward route to analogues and labeled forms.
