80944-47-4Relevant academic research and scientific papers
Synthesis of N-alkyl-N′-aryl-piperazines via copper-catalyzed C-N bond formation
Yavari, Issa,Bayat, Mohammad J.,Ghazanfarpour-Darjani, Majid
, p. 5595 - 5596 (2014/12/11)
An efficient copper-catalyzed tandem synthesis of N-alkyl-N′-aryl-piperazines from 1,4-diaza-bicyclo[2.2.2]octane, alkyl halides, and aryl halides in the presence of copper(I) iodide and potassium tert-butoxide in DMSO is described.
Structure-activity relationship studies of CNS agents, XIX: Quantitative analysis of the alkyl chain effects on the 5-HT(1A) and 5-HT2 receptor affinities of 4-alkyl-1-arylpiperazines and their analogs
Mokrosz,Mokrosz,Charakchieva-Minol,Paluchowska,Bojarski,Duszynska
, p. 143 - 148 (2007/10/02)
The 5-HT(1A) and 5-HT2 receptor affinity of a set of 44 N-alkylated 1-arylpiperazines and their analogs has been analyzed: the n-hexyl derivatives were the most potent and the most selective 5-HT(1A) ligands of all the investigated N-alkyl homologues. The alkyl chain may stablize the 5-HT(1A) receptor-ligand complex by hydrophobic forces. A set of the alkyl substituent contributions (C(HT1A)) for prediction of the 5-HT(1A) affinity of N-alkyl derivatives of 1-arylpiperazines and related compounds have been defined on the basis of the Free-Wilson analysis.
Phenylpiperazine-Based Radiopharmaceutical for Brain Imaging. 3. Synthesis and Evaluation of Radioiodinated 1-Alkyl-4-phenylpiperazines
Hanson, Robert N.,Hassan, Mohamad
, p. 29 - 34 (2007/10/02)
As part of our program in radiopharmaceutical chemistry we have prepared and evaluated a series of radioiodinated 1-alkyl-4-phenylpiperazines as potential brain-imaging agents.The compounds were chosen on the basis of their synthetic versatility, activati
