80967-26-6

Usage

Chemical class

Thioether compounds

Derivative of

Pyrazole

Usage

Organic synthesis, reagent in pharmaceutical and agricultural product preparation

Biological activities

Potential applications in medicine and materials science

Physical state

Yellow crystalline solid

Stability

Stable under normal conditions

Safety precautions

Handle with care due to potential hazardous properties

InChI:InChI=1/C16H14N2S/c1-19-16-12-15(13-8-4-2-5-9-13)18(17-16)14-10-6-3-7-11-14/h2-12H,1H3

Upstream product

• 99027-35-7 5-(thiomethyl)-3-phenylisothiazole 
• 51977-80-1 (Z)-3-Methylamino-3-phenyl-dithioacrylic acid methyl ester 
• 20365-21-3 methyl 3-oxo-3-phenylpropanedithioate 
• 100-63-0 phenylhydrazine 

Downstream Products

• 3729-90-6 3-methyl-1,5-diphenyl-1H-pyrazole 
• 33045-40-8 3-p-anisyl-1,5-diphenylpyrazole 
• 6831-89-6 1,5-diphenyl-1H-pyrazole 
• 113380-90-8 4-(4-methoxyphenyl)-1,5-diphenyl-1H-pyrazole 
• 36372-77-7 1,4,5-triphenyl-1H-pyrazole 
• 1296269-93-6 4-(2-furyl)-1,5-diphenyl-1H-pyrazole 
• 1296269-72-1 4-iodo-3-(methylthio)-1,5-diphenyl-1H-pyrazole 
• 1296269-90-3 4-(quinolin-3-yl)-3-(methylthio)-1,5-diphenyl-1H-pyrazole 
• 1296269-89-0 4-(benzofuran-2-yl)-3-(methylthio)-1,5-diphenyl-1H-pyrazole 
• 1296269-87-8 4-(1-benzenesulfonyl-1H-indol-3-yl)-3-(methylthio)-1,5-diphenyl-1H-pyrazole 
• 1296269-86-7 4-(1-methyl-1H-indol-5-yl)-3-(methylthio)-1,5-diphenyl-1H-pyrazole 
• 1296269-85-6 4-(pyridin-3-yl)-3-(methylthio)-1,5-diphenyl-1H-pyrazole 
• 1296269-84-5 4-(furan-2-yl)-3-(methylthio)-1,5-diphenyl-1H-pyrazole 
• 1296269-83-4 3-(methylthio)-1,5-diphenyl-4-(thiophen-2-yl)-1H-pyrazole 

Relevant academic research and scientific papers

Regioselective synthesis of 1-aryl-3,4-substituted/annulated-5-(methylthio) pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/annulated pyrazoles

Highly efficient and regioselective synthesis of 1-aryl-3,4-substituted/ annulated-5-(methylthio)-pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/ annulated pyrazoles has been reported via cyclocondensation of arylhydrazines with either α-oxoketene dithioacetals or β-oxodithioesters.

THE REACTIONS OF ISOTHIAZOLIUM SALTS WITH NITROGEN NUCLEOPHILIC REAGENTS

Isothiazolium salts were allowed to react with a number of nitrogen nucleophiles including ammonia, hydrazine, phenylhydrazine, hydroxylamine, and benzylamine.The products obtained suggest that the position of initial nucleophilic attack is at the sulphur