81-11-8Relevant articles and documents
Stilbene type compound as well as synthesis method and application thereof
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, (2021/07/01)
The invention discloses a stilbene type compound as well as a synthesis method and application thereof, wherein the synthesis method comprises the steps: taking an intermediate 2 and an intermediate 4 as initiators, sequentially carrying out Wittig reaction, reduction reaction, amino protection reaction, condensation reaction, deprotection reaction and amidation reaction, and then refining to obtain the stilbene type compound. The synthesis process is high in controllability, used reagents are low in price, and the method is simple and easy to industrialize. The stilbene type compound can be used as a medicine for resisting tumors and viruses and treating fungal infection and cardiovascular and cerebrovascular diseases.
A reduction of nitro aromatic substituent amino aromatic of substituted method (by machine translation)
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Paragraph 0043-0047; 0073-0077, (2019/06/13)
The invention relates to amino aromatic substituted object synthesis technology field, in particular to a process for preparing nitro aromatic substituent amino aromatic of substituted method. The method comprises the following steps, water, catalyst is added to the 1st in the reactor, and the reactor temperature, adding reducing iron, adjusting pH, at the same time added to the 1st nitro aromatic substituent in the reactor, thermal insulation reaction, to obtain a reaction liquid; regulating the reaction liquid of pH, thermal reaction, the addition of a stabilizing agent, containing the amino aromatic of substituted 1st solution and iron oxide black crude; adjusting the pH of the 1st solution, solid-liquid separation, obtained amino aromatic substituent. The present invention provides a process for the production of the method is simple, can be continuously produced, with high operation safety and higher selectivity, the reaction time is short, a yield as high as 90% or more, the product quality is good, the content of 98% or more. (by machine translation)
Preparation method of 4,4'-diamino diphenylethene-disulfonic acid
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Paragraph 0056; 0057; 0058; 0060, (2017/04/29)
The invention discloses a preparation method of 4,4'-diamino diphenylethene-disulfonic acid. 4,4'-binitro diphenylethene-disulfonic acid or 4,4'-binitro diphenylethene-disulfonate serves as a raw material, the raw material and a supported catalyst are co-dispersed in a solvent, and 4,4'-diamino diphenylethene-disulfonic acid is prepared through a hydrogenation reaction. Based on the total mass of the supported catalyst, active ingredients in the supported catalyst comprise, by mass, 0.1-10% of platinum, 0-5% of ruthenium and 0-5% of iridium, wherein the mass fraction of ruthenium and the mass fraction of iridium cannot be 0 at the same time. According to the preparation method of 4,4'-diamino diphenylethene-disulfonic acid, the high-activity and high-selectivity supported catalyst is adopted, and the produced product reaches the China chemical industry standard HG/T 2279-2011.