81000-11-5

Basic information

• Product Name: 6-AMINO-3-METHYL-4-PHENYL-4H-PYRANO[3,2-D]PYRAZOLE-5-CARBONITRILE
• Synonyms: 6-AMINO-3-METHYL-4-PHENYL-1,4-DIHYDRO-PYRANO[2,3-C]PYRAZOLE-5-CARBONITRILE;6-AMINO-3-METHYL-4-PHENYL-4H-PYRANO[3,2-D]PYRAZOLE-5-CARBONITRILE;AKOS PAO-1245;BUTTPARK 124\40-30;6-amino-3-methyl-4-phenyl-1H,4H-pyrano[2,3-c]pyrazole-5-carbonitrile
• CAS NO: 81000-11-5
• Molecular Formula: C₁₄H₁₂N₄O
• Molecular Weight: 252.27
• Mol File: 81000-11-5.mol
• Article Data: 144

Chemical Properties

• Melting Point: 245-246 °C(Solv: ethanol (64-17-5))
• Boiling Point: 539.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.38±0.1 g/cm3(Predicted)
• PKA: 11.62±0.70(Predicted)
• CAS DataBase Reference: 6-AMINO-3-METHYL-4-PHENYL-4H-PYRANO[3,2-D]PYRAZOLE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-3-METHYL-4-PHENYL-4H-PYRANO[3,2-D]PYRAZOLE-5-CARBONITRILE(81000-11-5)
• EPA Substance Registry System: 6-AMINO-3-METHYL-4-PHENYL-4H-PYRANO[3,2-D]PYRAZOLE-5-CARBONITRILE(81000-11-5)

Safety Data

• Hazardous Substances Data: 81000-11-5(Hazardous Substances Data)

Upstream product

• 68761-49-9 4-benzylidene-5-methyl-2,4-dihydro-3H-pyrazol-3-one 
• 109-77-3 malononitrile 
• 2700-22-3 Benzylidenemalononitrile 
• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 100-52-7 benzaldehyde 
• 15768-07-7 methyl 2-benzylidene-3-oxobutanoate 
• 141-97-9 ethyl acetoacetate 
• 7803-57-8 hydrazine hydrate 
• 79785-97-0 hydrazine hydrate 
• 100-39-0 benzyl bromide 
• 4344-87-0 3-hydroxy-5-methyl-1H-pyrazole 
• 2033-24-1 cycl-isopropylidene malonate 
• 75-36-5 acetyl chloride 
• 105-45-3 acetoacetic acid methyl ester 

Relevant articles and documents

Synthesis of Pyranopyrazoles using a Magnetically Separable Modified Preyssler Heteropoly Acid

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A new role for photoexcited Na2 eosin Y as direct hydrogen atom transfer (HAT) photocatalyst in photochemical synthesis of dihydropyrano[2,3-c]pyrazole scaffolds promoted by visible light irradiation under air atmosphere

Evidence indicates that Na2 eosin Y-derived photoexcited states functions as a direct hydrogen atom transfer (HAT) catalyst to synthesize dihydropyrano[2,3-c]pyrazole scaffolds photochemically via four-condensation domino reaction of tandem Knoevenagel-Michael cyclocondensation reaction ethyl acetoacetate, hydrazine hydrate, aryl aldehyde derivatives and malononitrile via visible light-mediated in aqueous ethanol at ambient temperature under air atmosphere. This study paves the new role for further the use of a metal-free organic dye with commercial availability and inexpensiveness, Na2 eosin Y in photochemical synthesis with use of the lowest amount of catalyst, excellent yields, time-saving aspects of the reaction and high atom economy. Notably, this cyclization is also runnable on the gram scale, which highlights the potentiality of using this reaction in industrial uses.

Preparation and characterization of Fe3O4@Cu-β-CD as a hybrid magnetic catalyst for the synthesis of dihydropyrano[2,3-c]pyrazoles in H2O

Abstract: Fe3O4@Cu-β-CD is a hybrid composite with high catalytic activity. Easy separation with an external magnet and recyclability are the advantages of this catalyst. The magnetic composite was characterized by TEM, FE-SEM, XRD,

A New Facile Ultrasound-Assisted Magnetic Nano-[CoFe2O4]-Catalyzed One-Pot Synthesis of Pyrano[2,3-c]pyrazoles

Pyrano[2,3-c]pyrazole derivatives have been synthesized through a one-pot multicomponent condensation of various aldehydes, dialdehydes, and ketones with malononitrile, ethyl acetoacetate, hydrazine hydrate (or phenylhydrazine) in the presence of magnetic

One-pot synthesis of 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles using sodium citrate as an organo-salt based catalyst in aqueous ethanol

Sodium citrate as a highly efficient catalyst is developed for the synthesis of functionalized 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles. This method involves a one-pot three-component reaction of aromatic aldehydes, malononitrile and 1,3

Nano cobalt ferrite encapsulated-silica particles bearing melamine as an easily recyclable catalyst for the synthesis of dihydropyrano[2,3-c]pyrazoles under green conditions

In this research, it was displayed an efficient method for synthesis of 6-amino-2,4-dihydropyrano[2,3-c] pyrazol-5-carbonitrile derivatives by using CoFe2O4 silica supported bearing melamine as a magnetic nanocatalyst. This nanocompo