81015-49-8

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-Thiazolyl)phenol is used as a key intermediate in the synthesis of pharmaceuticals for its potential role in the development of drugs targeting diseases such as cancer and inflammation. Its antimicrobial and antifungal properties contribute to the creation of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(2-Thiazolyl)phenol is utilized as an intermediate in the production of agrochemicals, leveraging its antimicrobial and antifungal properties to develop agricultural products that protect crops from various pathogens.
Used in Dye and Pigment Industry:
4-(2-Thiazolyl)phenol is employed as a building block in the synthesis of dyes and pigments, contributing to the development of a diverse range of colorants for various applications, including textiles, plastics, and printing inks.
Used in Organic Compounds Synthesis:
As an intermediate, 4-(2-Thiazolyl)phenol is used in the synthesis of other organic compounds, expanding its applications across different industries that rely on organic chemistry for product development.

InChI:InChI=1/C9H7NOS/c11-8-3-1-7(2-4-8)9-10-5-6-12-9/h1-6,11H

Upstream product

• 27088-84-2 2-(4-methoxyphenyl)-1,3-thiazole 
• 3034-53-5 2-bromo-1,3-thiazole 
• 540-38-5 p-Iodophenol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 2362-64-3 p-methoxythiobenzamide 
• 874-90-8 4-methoxybenzonitrile 
• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 5720-07-0 4-methoxyphenylboronic acid 

Downstream Products

• 602298-58-8 3,4-O-isopropylidene-1,6-di-O-(4-thiazol-2-yl-phenyl)-D-mannitol 
• 213315-39-0 2-[4-(4-methoxyphenoxy)phenyl]thiazole 
• 102150-81-2 (S)-2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>thiazole 
• 778581-58-1 5-bromo-2-(4-methoxyphenyl)-1,3-thiazole 
• 27088-84-2 2-(4-methoxyphenyl)-1,3-thiazole 
• 1267044-41-6 5-bromo-2-(4-ethoxyphenyl)thiazole 
• 929918-55-8 (R)-2-[4-(4-Thiazol-2-yl-phenoxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

VASCULAR ADHESION PROTEIN-1 (VAP-1) MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule Vascular Adhesion Protein- 1 (VAP-1) modulator compositions, pharmaceutical compositions, the use and preparation thereof.

NOVEL NUCLEOSIDE PHOSPHORAMIDATE COMPOUND AND USE THEREOF

The present invention provides a novel nucleoside phosphoramidate compound, or a stereoisomer, salt, hydrate, solvate or crystal thereof for the treatment of Flaviviridae family viral infection, especially hepatitis C viral infection. The present invention also provides the pharmaceutical composition comprising a compound of the present invention, or a stereoisomer, salt, hydrate, solvate or crystal thereof and a use of the compound or the composition of the present invention in the treatment of Flaviviridae family viral infection, especially hepatitis C viral infection. The compound of the present invention has a good anti-HCV effect.

Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives

Two series of novel diaryl ureas have been designed and synthesized, with their in vitro antitumor effect screened on human non-small cell lung cancer (NSCLC) cell line A549 and human breast cancer cell line MDA-MB-231. Some target compounds demonstrated significant inhibitory activities against both cell lines. Compared to contrast drug Sorafenib, 1b, 1d, 1f, 1i were found to demonstrate more potent antitumor activities. The structures of all the newly synthesized compounds were determined by 1H, 13C NMR, MS, IR and elementary analysis.

ARYL AMINO ACID DERIVATIVES AS INHIBITORS FOR TREATING INFLAMMATION

The present invention relates to a chemical genus of 3-(triaryl)-2-aminopropanol derivative inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention of inflammatory diseases and disorders. The compounds have general formula III: A particular embodiment is

BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION

The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: An example is

New potent C2-symmetric malaria plasmepsin I and II inhibitors.

A series of malaria plasmepsin (Plm) I and II inhibitors containing a C(2)-symmetric core structure have been synthesised and tested for protease inhibition activity. These compounds can be prepared using a straightforward synthesis involving a phenol nuc

Preparation of 2- and 5-aryl substituted thiazoles via palladium-catalyzed Negishi cross-coupling

2-Aryl substituted thiazoles 3a-k were prepared by oxidative insertion of zinc into 2-bromothiazole (1) followed by palladium(0)-catalyzed Negishi cross-coupling in a one-pot procedure. 5-Aryl substituted thiazoles 6a-i were prepared by regioselective C-5 lithiation of 2-(trimethylsilyl)thiazole (4) followed by transmetalation with zinc chloride and palladium(0)-catalyzed Negishi cross-coupling in a one-pot procedure. The synthetic sequences were combined to give 2,5-diaryl substituted thiazoles 8a,b and 10 via stepwise C-2 and C-5 arylation and vice versa.

β1-Selective Adrenoceptor Antagonists: Examples of the 2-phenyl>imidazole Class. 2

An attempt to develop a highly cardioselective β-adrenoceptor antagonist devoid of intrinsic sympathomimetic activity (ISA) focused on exploring structure-activity relationships around (S)--amino>-2-hydroxypropoxy>phen