81028-13-9Relevant academic research and scientific papers
A convergent and stereoselective total synthesis of phomolides G and H
Subba Reddy,Sivaramakrishna Reddy,Phaneendra Reddy,Yadav
, p. 501 - 504 (2014/03/21)
A stereoselective total synthesis of phomolides G and H, a polyketide natural products is described. The synthesis involves organocatalytic enantioselective asymmetric epoxidation, C1-Wittig olefination, and ring-closing metathesis as key steps. The use of organocatalytic MacMillan asymmetric epoxidation for the construction of two chiral centers of phomolides G and H makes this approach more attractive. Georg Thieme Verlag Stuttgart New York.
Stereocontrolled construction of tetrasubstituted tetrahydrofurans: Synthesis of 2,5-anhydro d-glucitol
Das, Biswanath,Kumar, Duddukuri Nandan
scheme or table, p. 6011 - 6013 (2010/11/21)
A highly stereoselective construction of 2,3,4,5-tetrasubstituted tetrahydrofurans has been accomplished by an unusual intramolecular 5-endo-tet cyclization of 2,3-epoxy alcohols involving hydroxyl nucleophile. The method has been utilized for the synthes
A New Method for the Dehydration of β-Hydroxy Sulfones: Synthesis of (E,S)-γ-Hydroxy-α,β-unsaturated Sulfones and (S)-ε-Hydroxy-(E,E)-α,γ-dienyl Sulfones
Kang, Suk-Ku,Park, Young-Won,Kim, Sung-Gyu,Jeon, Jae-Hoon
, p. 405 - 406 (2007/10/02)
Optically active (E,S)-γ-hydroxy-α,β-unsaturated sulfones and (S)-ε-hydroxy-(E,E)-α,γ-dienyl sulfones have been prepared in a one-pot dehydration procedure from β,γ-dihydroxy sulfones and δ,ε-dihydroxy allyl sulfones, respectively, via an elimination reac
STEREOCONTROLLED TOTAL SYNTHESIS OF THE MACROCYCLIC LACTONE (-)-ASPICILIN
Waanders, P.P.,Thijs, L.,Zwanenburg, B.
, p. 2409 - 2412 (2007/10/02)
The essential features of the enantiocontrolled total synthesis of (-)-aspicilin are the strategic use of the photochemical rearrangement of α,β-epoxy diazomethyl ketones to 4-hydroxyalkenoates (Scheme 1) and the stereochemical control of the Sharpless epoxidation, α,ο functionalization of an alkynol using potassium 3-aminopropylamine (KAPA) as acetylene zipper, coupling between C7 and C8 by means of a Wittig reaction and lactonization by using 2,6-dichlorobenzoyl chloride.
Synthesis of Saccharides and Related Polyhydroxylated Natural Products. 1. Simple Alditols
Katsuki, T.,Lee, A. W. M.,Ma, P.,Martin, V. S.,Masamune, S.,et al.
, p. 1373 - 1378 (2007/10/02)
A new approach to sugar synthesis is demonstrated through syntheses of tetritols, pentitols, and hexitols; titanium-catalyzed asymmetric epoxidation and a new selective opening reaction of 2,3-epoxy alcohols play essential roles.
